Plant biosystems design research roadmap 1.0

Xiaohan Yang, June I. Medford, Kasey Markel, Patrick M. Shih, Henrique C. De Paoli, Cong T. Trinh, Alistair J McCormick, Raphael Ployet, Steven Hussey, Alexander A. Myburg, Poul Erik Jensen, Md Mahmudul Hassan, Jin Zhang, Wellington Muchero, Udaya C. Kalluri, Yin Hengfu, Renying Zhuo, Paul E. Abraham, Jin Gui Chen, David J. WestonYinong Yang, Degao Liu, Yi Li, Jessy Labbe, Bing Yang, Jun Hyung Lee, Robert W. Cottingham, Stanton Martin, Mengzhu Lu, Timothy J. Tschaplinski, Timothy J. Tschaplinski, Guoliang Yuan, Priya Ranjan, Julie C. Mitchell, Stan D. Wullschleger, Gerald A. Tuskan

Research output: Contribution to journalArticlepeer-review

Abstract

Human life intimately depends on plants for food, biomaterials, health, energy, and a favorable environment. Various plants have been genetically improved mostly through breeding, along with limited modification via genetic engineering, yet they are still not able to meet the ever-increasing needs, in terms of both quantity and quality, resulting from the rapid increase in world population and expected standards of living. A step change that may address these challenges would be to expand the potential of plants using biosystems design approaches. This represents a shift in plant science research from relatively simple trial-and-error approaches to innovative strategies based on predictive models of biological systems. Plant biosystems design seeks to accelerate plant genetic improvement using genome-editing and genetic circuit engineering, or create novel plant systems through de novo synthesis of plant genomes. From this perspective, we present a comprehensive roadmap of plant biosystems design covering theories, principles, and technical methods, along with potential applications in basic and applied plant biology research. We highlight current challenges, future opportunities, and research priorities, along with a framework for international collaboration, towards rapid advancement of this emerging interdisciplinary area of research. Finally, we discuss the importance of social responsibility in utilizing plant biosystems design and suggest strategies for improving public perception, trust, and acceptance.
Original languageEnglish
Article number8051764
Number of pages38
JournalBioDesign Research
DOIs
Publication statusPublished - 5 Dec 2020

Keywords

  • roadmap
  • biosystems design
  • synthetic biology
  • plant
  • systems biology

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