Plant cell culture strategies for the production of natural products

Ochoa-Villarreal Marisol Ochoa-Villarreal, Susan Howat, Sun Mi Hong, Mi Ok Jang, Young Woo Jin, Eun Kyong Lee, Gary J. Loake*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Plants have evolved a vast chemical cornucopia to support their sessile lifestyles. Man has exploited this natural resource since Neolithic times and currently plant-derived chemicals are exploited for a myriad of applications. However, plant sources of most high-value natural products (NPs) are not do- mesticated and therefore their production cannot be undertaken on an agricultural scale. Further, these plant species are often slow growing, their populations limiting, the concentration of the target molecule highly variable and routinely present at extremely low concentrations. Plant cell and organ culture constitutes a sustainable, controllable and environ- mentally friendly tool for the industrial production of plant NPs. Further, advances in cell line selection, biotransformation, product secretion, cell permeabilisation, extraction and scale-up, among others, are driving increases in plant NP yields. However, there remain significant obstacles to the com- mercial synthesis of high-value chemicals from these sources. The relatively recent isolation, culturing and characterisation of cambial meristematic cells (CMCs), provides an emerging platform to circumvent many of these potential difficulties.

Original languageEnglish
Pages (from-to)149-158
Number of pages10
JournalBMB Reports
Volume49
Issue number3
DOIs
Publication statusPublished - 1 Mar 2016

Keywords

  • Cambial meristematic cells
  • Hairy root culture
  • Natural products
  • Plant bioreactors
  • Plant cell culture

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