Plant Polycomb-Group Proteins: Epigenetic regulators of development

Pumi Perera, William Goodrich

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

Abstract

Although all cells in a multi cellular organism contain the same set of genes, the spatiotemporal expression of these genes needs to be dynamically regulated for proper development(i.e. morphogenesis and life cycle transitions) to take place. Epigenetic mechanisms (i.e. heritable but reversible changes to chromatin) are important to maintain such gene expression patterns. Polycomb-group proteins are evolutionarily conserved epigenetic regulators that function – via epigenetic marks such as his tone modifications and alterations to chromatin structure – to maintain the repression of developmentally important genes so that these genes are expressed appropriately.Although they maintain specific patterns of gene repression, Polycomb-group proteins are ubiquitously expressed. How their activity is regulated is a largely unexplored area but recentre search in both metazoans and plants suggests myriad methods of regulation, including control of RNA (ribonucleic acid) and protein abundance and stability, post-translational modifications and interactions with proteins and noncoding RNAs.
Original languageEnglish
Title of host publicationeLS
PublisherWiley
Pages1-12
Number of pages12
DOIs
Publication statusPublished - 15 Sep 2016

Keywords

  • Polycomb‐group
  • H3K27me3
  • PRC2
  • PRC1
  • repression
  • epigenetic regulators

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