Plantwide design and economic evaluation of two Continuous Pharmaceutical Manufacturing (CPM) cases: Ibuprofen and Artemisinin

Hikaru G. Jolliffe, Dimitrios Gerogiorgis

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract

Continuous Pharmaceutical Manufacturing (CPM) is a rapidly expanding research field with growing industrial importance: challenging the current batch production paradigm, it has a documented potential to deliver key cost, efficiency and environmental benefits. Ibuprofen, the potent painkiller, and artemisinin, a highly effective anti-malarial drug, have been identified as promising CPM candidates, and steady-state flowsheet models have been developed on the basis of published continuous organic synthesis pathways. Reactor design has been conducted using original kinetic parameter estimation results. A comparative economic analysis via published recoveries has computed performance indices which indicate that both CPM designs exhibit high economic potential even with conservative profit and climate estimates used toward capital and operating cost. More detailed technoeconomic analyses can facilitate quicker CPM implementation.
Original languageEnglish
Title of host publication12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering
EditorsKrist V. Gernaey, Jakob K. Huusom, Rafiqul Gani
Place of PublicationAMSTERDAM
PublisherElsevier B.V.
Pages2213-2218
Number of pages6
Volume9780444634290
DOIs
Publication statusPublished - 2015

Publication series

NameComputer-Aided Chemical Engineering
ISSN (Print)1570-7946

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