Projects per year
Abstract
Long-lived plasma cells (LLPCs) that maintain humoral immunity to previously encountered Ags occupy a compartment in the bone marrow (BM). The rules and mechanisms by which cells enter (and leave) this compartment are poorly understood. We looked at what happens to the LLPC compartment and to plasma cell lifespan in general, in situations in which Ag stimulation and/or inflammation persist. We find that chronic Ag supply causes the generation of short-lived plasma cells in the local lymphoid organ, at the expense of any LLPC production. Furthermore, we find that inflammation caused by infection (mediated via TNF-α) causes a dramatic mobilization of LLPCs from the BM, with a concomitant reduction in circulating Ab levels against previously immunized Ags. These data are discussed in the context of the capacity of the BM LLPC compartment and competition for entry to it.
Original language | English |
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Pages (from-to) | 3128-38 |
Number of pages | 11 |
Journal | The Journal of Immunology |
Volume | 191 |
Issue number | 6 |
DOIs | |
Publication status | Published - 15 Sept 2013 |
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Dive into the research topics of 'Plasma cell homeostasis: the effects of chronic antigen stimulation and inflammation'. Together they form a unique fingerprint.Projects
- 2 Finished
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PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY
Iredale, J. (Principal Investigator)
1/09/12 → 31/08/16
Project: Research
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ANTI INFLAMMATORY CELL CONTACT
Gray, M. (Principal Investigator) & Gray, D. (Co-investigator)
1/05/12 → 30/09/15
Project: Research