Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer

R J E Skipworth, D A C Deans, B H L Tan, K Sangster, S Paterson-Brown, D A Brown, M Hunter, S N Breit, James Ross, K C H Fearon, Kenneth Fearon

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

BACKGROUND: Macrophage inhibitory cytokine-1(MIC-1) is a potential modulator of systemic inflammation and nutritional depletion, both of which are adverse prognostic factors in oesophago-gastric cancer (OGC).

METHODS: Plasma MIC-1, systemic inflammation (defined as plasma C-reactive protein (CRP) of >= 10 mg l(-1) or modified Glasgow prognostic score (mGPS) of >= 1),and nutritional status were assessed in newly diagnosed OGC patients (n = 293). Healthy volunteers (n = 35) served as controls.

RESULTS: MIC-1 was elevated in patients (median 1371 pg ml(-1); range 141-39 053) when compared with controls (median 377 pg ml(-1); range 141-3786; P<0.001). Patients with gastric tumours (median 1592 pg ml(-1); range 141-12 643) showed higher MIC-1 concentrations than patients with junctional (median 1337 pg ml(-1); range 383-39 053) and oesophageal tumours (median 1180 pg ml(-1); range 258-31 184; P = 0.015). Patients showed a median weight loss of 6.4% (range 0.0-33.4%), and 42% of patients had an mGPS of >= 1 or plasma CRP of >= 10 mg l(-1) (median 9 mg l(-1); range 1-200). MIC-1 correlated positively with disease stage (r(2) = 0.217; P<0.001), age (r(2) = 0.332; P<0.001), CRP (r(2) = 0.314; P<0.001), and mGPS (r(2) = 0.336; P<0.001), and negatively with Karnofsky Performance Score (r(2) = -0.269; P<0.001). However, although MIC-1 correlated weakly with dietary intake (r(2) = 0.157; P = 0.031), it did not correlate with weight loss, BMI, or anthropometry. Patients with MIC-1 levels in the upper quartile showed reduced survival (median 204 days; 95% CI 157-251) when compared with patients with MIC-1 levels in the lower three quartiles (median 316 days; 95% CI 259-373; P = 0.036), but MIC-1 was not an independent prognostic indicator.

CONCLUSIONS: There is no independent link between plasma MIC-1 levels and depleted nutritional status or survival in OGC. British Journal of Cancer (2010) 102, 665-672. doi:10.1038/sj.bjc.6605532 Published online 26 January 2010 (C) 2010 Cancer Research UK
Original languageEnglish
Pages (from-to)665-72
Number of pages8
JournalBritish Journal of Cancer
Issue number4
Publication statusPublished - Feb 2010

Keywords / Materials (for Non-textual outputs)

  • Adenocarcinoma
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Esophageal Neoplasms
  • Female
  • Growth Differentiation Factor 15
  • Humans
  • Inflammation
  • Inflammation Mediators
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Nutritional Status
  • Prognosis
  • Stomach Neoplasms
  • Survival Analysis


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