Abstract / Description of output
BACKGROUND: Macrophage inhibitory cytokine-1(MIC-1) is a potential modulator of systemic inflammation and nutritional depletion, both of which are adverse prognostic factors in oesophago-gastric cancer (OGC).
METHODS: Plasma MIC-1, systemic inflammation (defined as plasma C-reactive protein (CRP) of >= 10 mg l(-1) or modified Glasgow prognostic score (mGPS) of >= 1),and nutritional status were assessed in newly diagnosed OGC patients (n = 293). Healthy volunteers (n = 35) served as controls.
RESULTS: MIC-1 was elevated in patients (median 1371 pg ml(-1); range 141-39 053) when compared with controls (median 377 pg ml(-1); range 141-3786; P<0.001). Patients with gastric tumours (median 1592 pg ml(-1); range 141-12 643) showed higher MIC-1 concentrations than patients with junctional (median 1337 pg ml(-1); range 383-39 053) and oesophageal tumours (median 1180 pg ml(-1); range 258-31 184; P = 0.015). Patients showed a median weight loss of 6.4% (range 0.0-33.4%), and 42% of patients had an mGPS of >= 1 or plasma CRP of >= 10 mg l(-1) (median 9 mg l(-1); range 1-200). MIC-1 correlated positively with disease stage (r(2) = 0.217; P<0.001), age (r(2) = 0.332; P<0.001), CRP (r(2) = 0.314; P<0.001), and mGPS (r(2) = 0.336; P<0.001), and negatively with Karnofsky Performance Score (r(2) = -0.269; P<0.001). However, although MIC-1 correlated weakly with dietary intake (r(2) = 0.157; P = 0.031), it did not correlate with weight loss, BMI, or anthropometry. Patients with MIC-1 levels in the upper quartile showed reduced survival (median 204 days; 95% CI 157-251) when compared with patients with MIC-1 levels in the lower three quartiles (median 316 days; 95% CI 259-373; P = 0.036), but MIC-1 was not an independent prognostic indicator.
CONCLUSIONS: There is no independent link between plasma MIC-1 levels and depleted nutritional status or survival in OGC. British Journal of Cancer (2010) 102, 665-672. doi:10.1038/sj.bjc.6605532 www.bjcancer.com Published online 26 January 2010 (C) 2010 Cancer Research UK
METHODS: Plasma MIC-1, systemic inflammation (defined as plasma C-reactive protein (CRP) of >= 10 mg l(-1) or modified Glasgow prognostic score (mGPS) of >= 1),and nutritional status were assessed in newly diagnosed OGC patients (n = 293). Healthy volunteers (n = 35) served as controls.
RESULTS: MIC-1 was elevated in patients (median 1371 pg ml(-1); range 141-39 053) when compared with controls (median 377 pg ml(-1); range 141-3786; P<0.001). Patients with gastric tumours (median 1592 pg ml(-1); range 141-12 643) showed higher MIC-1 concentrations than patients with junctional (median 1337 pg ml(-1); range 383-39 053) and oesophageal tumours (median 1180 pg ml(-1); range 258-31 184; P = 0.015). Patients showed a median weight loss of 6.4% (range 0.0-33.4%), and 42% of patients had an mGPS of >= 1 or plasma CRP of >= 10 mg l(-1) (median 9 mg l(-1); range 1-200). MIC-1 correlated positively with disease stage (r(2) = 0.217; P<0.001), age (r(2) = 0.332; P<0.001), CRP (r(2) = 0.314; P<0.001), and mGPS (r(2) = 0.336; P<0.001), and negatively with Karnofsky Performance Score (r(2) = -0.269; P<0.001). However, although MIC-1 correlated weakly with dietary intake (r(2) = 0.157; P = 0.031), it did not correlate with weight loss, BMI, or anthropometry. Patients with MIC-1 levels in the upper quartile showed reduced survival (median 204 days; 95% CI 157-251) when compared with patients with MIC-1 levels in the lower three quartiles (median 316 days; 95% CI 259-373; P = 0.036), but MIC-1 was not an independent prognostic indicator.
CONCLUSIONS: There is no independent link between plasma MIC-1 levels and depleted nutritional status or survival in OGC. British Journal of Cancer (2010) 102, 665-672. doi:10.1038/sj.bjc.6605532 www.bjcancer.com Published online 26 January 2010 (C) 2010 Cancer Research UK
| Original language | English |
|---|---|
| Pages (from-to) | 665-72 |
| Number of pages | 8 |
| Journal | British Journal of Cancer |
| Volume | 102 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Feb 2010 |
Keywords / Materials (for Non-textual outputs)
- Adenocarcinoma
- Adult
- Aged
- Aged, 80 and over
- Case-Control Studies
- Esophageal Neoplasms
- Female
- Growth Differentiation Factor 15
- Humans
- Inflammation
- Inflammation Mediators
- Male
- Middle Aged
- Neoplasm Staging
- Nutritional Status
- Prognosis
- Stomach Neoplasms
- Survival Analysis