Plasma vitamin C, cholesterol and homocysteine are associated with grey matter volume determined by MRI in non-demented old people

L J  Whalley; R T  Staff; A D  Murray; S J  Duthie; A R  Collins; H A  Lemmon; John Starr; I J  Deary

doi:10.1016/S0304-3940(02)01452-0

Plasma vitamin C, cholesterol and homocysteine are associated with grey matter volume determined by MRI in non-demented old people

L J Whalley, R T Staff, A D Murray, S J Duthie, A R Collins, H A Lemmon, John Starr, I J Deary

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

We studied 82 non-demented old people and, using MRI, derived measures of grey and white matter and intracranial volumes. Controlling for sex and intracranial volume, we related grey and white matter volumes to plasma concentrations of vitamins C, B-12, folate, homocysteine, cholesterol, triglycerides, high density and low density (LDL) lipoproteins, and to red blood cell folate and glycated haemoglobin concentrations (HbA1(c)). We found that lower grey matter volume was associated with lower plasma vitamin C and higher homocysteine, cholesterol and LDL. Lower blood cell folate was also associated with lower grey matter volume but HbA1(c) was not. These data are consistent with the putative benefits of dietary vitamin C and folate intake and the role of cholesterol in age related neurodegeneration. (C) 2003 Published by Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	173-176
Number of pages	4
Journal	Neuroscience Letters
Volume	341
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(02)01452-0
Publication status	Published - 8 May 2003

Keywords / Materials (for Non-textual outputs)

Alzheimer's disease
low density lipoproteins
high density lipoproteins
brain grey matter shrinkage
advanced glycation end-products
glycated haemoglobin
ALZHEIMERS-DISEASE
BRAIN
ACID

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10.1016/S0304-3940(02)01452-0

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@article{246df2a0694c451b88460d10ff84be37,

title = "Plasma vitamin C, cholesterol and homocysteine are associated with grey matter volume determined by MRI in non-demented old people",

abstract = "We studied 82 non-demented old people and, using MRI, derived measures of grey and white matter and intracranial volumes. Controlling for sex and intracranial volume, we related grey and white matter volumes to plasma concentrations of vitamins C, B-12, folate, homocysteine, cholesterol, triglycerides, high density and low density (LDL) lipoproteins, and to red blood cell folate and glycated haemoglobin concentrations (HbA1(c)). We found that lower grey matter volume was associated with lower plasma vitamin C and higher homocysteine, cholesterol and LDL. Lower blood cell folate was also associated with lower grey matter volume but HbA1(c) was not. These data are consistent with the putative benefits of dietary vitamin C and folate intake and the role of cholesterol in age related neurodegeneration. (C) 2003 Published by Elsevier Science Ireland Ltd.",

keywords = "Alzheimer's disease, low density lipoproteins, high density lipoproteins, brain grey matter shrinkage, advanced glycation end-products, glycated haemoglobin, ALZHEIMERS-DISEASE, BRAIN, ACID",

author = "Whalley, {L J} and Staff, {R T} and Murray, {A D} and Duthie, {S J} and Collins, {A R} and Lemmon, {H A} and John Starr and Deary, {I J}",

year = "2003",

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doi = "10.1016/S0304-3940(02)01452-0",

language = "English",

volume = "341",

pages = "173--176",

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TY - JOUR

T1 - Plasma vitamin C, cholesterol and homocysteine are associated with grey matter volume determined by MRI in non-demented old people

AU - Whalley, L J

AU - Staff, R T

AU - Murray, A D

AU - Duthie, S J

AU - Collins, A R

AU - Lemmon, H A

AU - Starr, John

AU - Deary, I J

PY - 2003/5/8

Y1 - 2003/5/8

N2 - We studied 82 non-demented old people and, using MRI, derived measures of grey and white matter and intracranial volumes. Controlling for sex and intracranial volume, we related grey and white matter volumes to plasma concentrations of vitamins C, B-12, folate, homocysteine, cholesterol, triglycerides, high density and low density (LDL) lipoproteins, and to red blood cell folate and glycated haemoglobin concentrations (HbA1(c)). We found that lower grey matter volume was associated with lower plasma vitamin C and higher homocysteine, cholesterol and LDL. Lower blood cell folate was also associated with lower grey matter volume but HbA1(c) was not. These data are consistent with the putative benefits of dietary vitamin C and folate intake and the role of cholesterol in age related neurodegeneration. (C) 2003 Published by Elsevier Science Ireland Ltd.

AB - We studied 82 non-demented old people and, using MRI, derived measures of grey and white matter and intracranial volumes. Controlling for sex and intracranial volume, we related grey and white matter volumes to plasma concentrations of vitamins C, B-12, folate, homocysteine, cholesterol, triglycerides, high density and low density (LDL) lipoproteins, and to red blood cell folate and glycated haemoglobin concentrations (HbA1(c)). We found that lower grey matter volume was associated with lower plasma vitamin C and higher homocysteine, cholesterol and LDL. Lower blood cell folate was also associated with lower grey matter volume but HbA1(c) was not. These data are consistent with the putative benefits of dietary vitamin C and folate intake and the role of cholesterol in age related neurodegeneration. (C) 2003 Published by Elsevier Science Ireland Ltd.

KW - Alzheimer's disease

KW - low density lipoproteins

KW - high density lipoproteins

KW - brain grey matter shrinkage

KW - advanced glycation end-products

KW - glycated haemoglobin

KW - ALZHEIMERS-DISEASE

KW - BRAIN

KW - ACID

U2 - 10.1016/S0304-3940(02)01452-0

DO - 10.1016/S0304-3940(02)01452-0

M3 - Article

SN - 0304-3940

VL - 341

SP - 173

EP - 176

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Plasma vitamin C, cholesterol and homocysteine are associated with grey matter volume determined by MRI in non-demented old people

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Keywords / Materials (for Non-textual outputs)

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