Plasmacytoid dendritic cells respond directly to apoptotic cells by secreting immune regulatory IL-10 or IFN-α

Joanne Simpson, Katherine Miles, Marta Trub, Roisin MacMahon, Mohini Gray

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Plasmacytoid dendritic cells (pDCs) play a pivotal role in driving the autoimmune disease systemic lupus erythematosus, via the secretion of IFNa in response to nuclear self-antigens complexed with autoantibodies. Apoptotic cells, generated at sites of inflammation or secondary lymphoid organs, are exposed to activated pDCs and also express the same nuclear antigens on their cell surface. Here we show, that in the absence of autoantibodies, activated pDCs directly respond to apoptotic cell expressed chromatin complexes by secreting IL-10 and IL-6, which also induces T cells to secrete IL-10. Conversely, when activated by the viral mimetic CpGA, apoptotic cells enhance their secretion of IFN-a. This study demonstrates that activated pDCs respond directly to apoptotic cells and may maintain tolerance via IL-10, or promote inflammation through secretion of IFNa, depending on the inflammatory context.
Original languageEnglish
JournalFrontiers in Immunology
DOIs
Publication statusPublished - 14 Dec 2016

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