Plasmodium chabaudi limits early Nippostrongylus brasiliensis-induced pulmonary immune activation and Th2 polarization in co-infected mice

Marieke A Hoeve, Katie J Mylonas, Karen J Fairlie-Clarke, Simmi M Mahajan, Judith E Allen, Andrea L Graham

Research output: Contribution to journalArticlepeer-review

Abstract

Larvae of several common species of parasitic nematodes obligately migrate through, and often damage, host lungs. The larvae induce strong pulmonary Type 2 immune responses, including T-helper (Th)2 cells as well as alternatively activated macrophages (AAMphi) and associated chitinase and Fizz/resistin family members (ChaFFs), which are thought to promote tissue repair processes. Given the prevalence of systemic or lung-resident Type 1-inducing pathogens in geographical areas in which nematodes are endemic, we wished to investigate the impact of concurrent Type 1 responses on the development of these Type 2 responses to nematode larval migration. We therefore infected BALB/c mice with the nematode Nippostrongylus brasiliensis, in the presence or absence of Plasmodium chabaudi chabaudi malaria parasites. Co-infected animals received both infections on the same day, and disease was assessed daily before immunological measurements were taken at 3, 5, 7 or 20 days post-infection.
Original languageEnglish
Article number60
JournalBMC Immunology
Volume10
DOIs
Publication statusPublished - 2009

Keywords

  • Anemia
  • Animals
  • Female
  • Larva
  • Lung
  • Lymphocyte Activation
  • Malaria
  • Mice
  • Mice, Inbred BALB C
  • Nippostrongylus
  • Plasmodium chabaudi
  • Strongylida Infections
  • Th1 Cells
  • Th2 Cells
  • Wound Healing

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