Plasmodium Cysteine Repeat Modular Proteins 3 and 4 are essential for malaria parasite transmission from the mosquito to the host

Bruno Douradinha; Kevin D Augustijn; Sally G Moore; Jai Ramesar; Maria M Mota; Andrew P Waters; Chris J Janse; Joanne Thompson

doi:10.1186/1475-2875-10-71

Plasmodium Cysteine Repeat Modular Proteins 3 and 4 are essential for malaria parasite transmission from the mosquito to the host

Bruno Douradinha, Kevin D Augustijn, Sally G Moore, Jai Ramesar, Maria M Mota, Andrew P Waters, Chris J Janse, Joanne Thompson

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The Plasmodium Cysteine Repeat Modular Proteins (PCRMP) are a family of four conserved proteins of malaria parasites, that contain a number of motifs implicated in host-parasite interactions. Analysis of mutants of the rodent parasite Plasmodium berghei lacking expression of PCRMP1 or 2 showed that these proteins are essential for targeting of P. berghei sporozoites to the mosquito salivary gland and, hence, for transmission from the mosquito to the mouse.

Original language	English
Article number	71
Journal	Malaria Journal
Volume	10
DOIs	https://doi.org/10.1186/1475-2875-10-71
Publication status	Published - 2011

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abstract = "The Plasmodium Cysteine Repeat Modular Proteins (PCRMP) are a family of four conserved proteins of malaria parasites, that contain a number of motifs implicated in host-parasite interactions. Analysis of mutants of the rodent parasite Plasmodium berghei lacking expression of PCRMP1 or 2 showed that these proteins are essential for targeting of P. berghei sporozoites to the mosquito salivary gland and, hence, for transmission from the mosquito to the mouse.",

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AU - Augustijn, Kevin D

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AU - Ramesar, Jai

AU - Mota, Maria M

AU - Waters, Andrew P

AU - Janse, Chris J

AU - Thompson, Joanne

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AB - The Plasmodium Cysteine Repeat Modular Proteins (PCRMP) are a family of four conserved proteins of malaria parasites, that contain a number of motifs implicated in host-parasite interactions. Analysis of mutants of the rodent parasite Plasmodium berghei lacking expression of PCRMP1 or 2 showed that these proteins are essential for targeting of P. berghei sporozoites to the mosquito salivary gland and, hence, for transmission from the mosquito to the mouse.

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DO - 10.1186/1475-2875-10-71

M3 - Article

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JO - Malaria Journal

JF - Malaria Journal

SN - 1475-2875

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Plasmodium Cysteine Repeat Modular Proteins 3 and 4 are essential for malaria parasite transmission from the mosquito to the host

Abstract

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