Platination of superoxide dismutase with cisplatin: tracking the ammonia ligands using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS)

Stefan K Weidt, C Logan Mackay, Pat R R Langridge-Smith, Peter J Sadler

Research output: Contribution to journalArticlepeer-review

Abstract

The high mass accuracy of FT-ICR MS combined with (15)N-labelling shows that mono- and di- platinated products from the reaction of erythrocyte superoxide dismutase with the anticancer drug cisplatin in solution retain their ammine ligands, in contrast to a recent X-ray crystallographic study.
Original languageEnglish
Pages (from-to)1719-21
Number of pages3
JournalChemical Communications
Issue number17
DOIs
Publication statusPublished - 2007

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