Platination of superoxide dismutase with cisplatin: tracking the ammonia ligands using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS)

Stefan K Weidt; C Logan Mackay; Pat R R Langridge-Smith; Peter J Sadler

doi:10.1039/b701903c

Platination of superoxide dismutase with cisplatin: tracking the ammonia ligands using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS)

Stefan K Weidt, C Logan Mackay, Pat R R Langridge-Smith, Peter J Sadler

Research output: Contribution to journal › Article › peer-review

Abstract

The high mass accuracy of FT-ICR MS combined with (15)N-labelling shows that mono- and di- platinated products from the reaction of erythrocyte superoxide dismutase with the anticancer drug cisplatin in solution retain their ammine ligands, in contrast to a recent X-ray crystallographic study.

Original language	English
Pages (from-to)	1719-21
Number of pages	3
Journal	Chemical Communications
Issue number	17
DOIs	https://doi.org/10.1039/b701903c
Publication status	Published - 2007

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title = "Platination of superoxide dismutase with cisplatin: tracking the ammonia ligands using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS)",

abstract = "The high mass accuracy of FT-ICR MS combined with (15)N-labelling shows that mono- and di- platinated products from the reaction of erythrocyte superoxide dismutase with the anticancer drug cisplatin in solution retain their ammine ligands, in contrast to a recent X-ray crystallographic study.",

author = "Weidt, \{Stefan K\} and Mackay, \{C Logan\} and Langridge-Smith, \{Pat R R\} and Sadler, \{Peter J\}",

year = "2007",

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journal = "Chemical Communications",

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AU - Weidt, Stefan K

AU - Mackay, C Logan

AU - Langridge-Smith, Pat R R

AU - Sadler, Peter J

PY - 2007

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AB - The high mass accuracy of FT-ICR MS combined with (15)N-labelling shows that mono- and di- platinated products from the reaction of erythrocyte superoxide dismutase with the anticancer drug cisplatin in solution retain their ammine ligands, in contrast to a recent X-ray crystallographic study.

U2 - 10.1039/b701903c

DO - 10.1039/b701903c

M3 - Article

C2 - 17457419

SN - 1359-7345

SP - 1719

EP - 1721

JO - Chemical Communications

JF - Chemical Communications

IS - 17

ER -

Platination of superoxide dismutase with cisplatin: tracking the ammonia ligands using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS)

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