Ploidy dynamics increase the risk of liver cancer initiation

Miryam Müller; Stephanie May; Thomas G. Bird

doi:10.1038/s41467-021-21897-8

Ploidy dynamics increase the risk of liver cancer initiation

Miryam Müller, Stephanie May, Thomas G. Bird

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Liver cancer typically arises after years of inflammatory insults to hepatocytes.
These cells can change their ploidy state during health and disease. Whilst
polyploidy may offer some protection, new research shows it may also promote
the formation of liver tumours.

Original language	English
Journal	Nature Communications
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41467-021-21897-8
Publication status	Published - 25 Mar 2021

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s41467-021-21897-8
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http://www.nature.com/articles/s41467-021-21897-8

Cite this

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title = "Ploidy dynamics increase the risk of liver cancer initiation",

abstract = "Liver cancer typically arises after years of inflammatory insults to hepatocytes.These cells can change their ploidy state during health and disease. Whilstpolyploidy may offer some protection, new research shows it may also promotethe formation of liver tumours.",

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Ploidy dynamics increase the risk of liver cancer initiation

Abstract

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