Ploidy dynamics increase the risk of liver cancer initiation

Miryam Müller; Stephanie May; Thomas G. Bird

doi:10.1038/s41467-021-21897-8

Ploidy dynamics increase the risk of liver cancer initiation

Miryam Müller, Stephanie May, Thomas G. Bird

Deanery of Clinical Sciences

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Liver cancer typically arises after years of inflammatory insults to hepatocytes.
These cells can change their ploidy state during health and disease. Whilst
polyploidy may offer some protection, new research shows it may also promote
the formation of liver tumours.

Original language	English
Article number	1896
Number of pages	4
Journal	Nature Communications
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41467-021-21897-8
Publication status	Published - 25 Mar 2021

Keywords / Materials (for Non-textual outputs)

cancer genomics
chromosome segregation

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10.1038/s41467-021-21897-8

s41467-021-21897-8
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Final published version, 451 KBLicence: Creative Commons: Attribution (CC-BY)

http://www.nature.com/articles/s41467-021-21897-8

Cite this

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title = "Ploidy dynamics increase the risk of liver cancer initiation",

abstract = "Liver cancer typically arises after years of inflammatory insults to hepatocytes.These cells can change their ploidy state during health and disease. Whilstpolyploidy may offer some protection, new research shows it may also promotethe formation of liver tumours.",

keywords = "cancer genomics, chromosome segregation",

author = "Miryam M{\"u}ller and Stephanie May and Bird, {Thomas G.}",

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AU - Müller, Miryam

AU - May, Stephanie

AU - Bird, Thomas G.

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N2 - Liver cancer typically arises after years of inflammatory insults to hepatocytes.These cells can change their ploidy state during health and disease. Whilstpolyploidy may offer some protection, new research shows it may also promotethe formation of liver tumours.

AB - Liver cancer typically arises after years of inflammatory insults to hepatocytes.These cells can change their ploidy state during health and disease. Whilstpolyploidy may offer some protection, new research shows it may also promotethe formation of liver tumours.

KW - cancer genomics

KW - chromosome segregation

U2 - 10.1038/s41467-021-21897-8

DO - 10.1038/s41467-021-21897-8

M3 - Comment/debate

SN - 2041-1723

VL - 12

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 1896

ER -

Ploidy dynamics increase the risk of liver cancer initiation

Abstract

Keywords / Materials (for Non-textual outputs)

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Cite this