Pluripotent stem cell-derived hepatocytes: Potential and challenges in pharmacology

Dagmara Szkolnicka, Wenli Zhou, Balta Lucendo-Villarin, David C Hay

Research output: Contribution to journalArticlepeer-review

Abstract

The liver is a fascinating organ and performs a wide range of functions necessary for life. Because the hepatocyte is the major functional cell type found in the liver, it is important that we better understand its role in health and disease. Functional hepatocytes have been derived from many sources, including human stem cell populations. These models offer new opportunities to further our understanding of human liver biology from diverse genotypes and, in the future, to facilitate the development of novel medicines or cell-based therapies. This review discusses limitations in current cell-based models and the advantages offered by pluripotent stem cell-derived hepatocytes.
Original languageEnglish
Pages (from-to)147-159
Number of pages13
JournalAnnual review of pharmacology and toxicology
Volume53
DOIs
Publication statusPublished - Jan 2013

Keywords

  • human embryonic stem cell
  • induced pluripotent stem cell
  • cytochrome p450 metabolism
  • drug-induced liver injury
  • genetics

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