Pneumonia and urinary tract infection after acute ischaemic stroke: a tertiary analysis of the GAIN International trial

S Aslanyan*, CJ Weir, HC Diener, M Kaste, KR Lees

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The third most common stroke complication is infection. We studied the rates of aspiration pneumonia and urinary tract infection (UTI), their risk factors and their effect on outcome in the 1455 Glycine Antagonist (Gavestinel) in Neuroprotection (GAIN) International patients with ischaemic stroke. Forward stepwise logistic regression and Cox proportional hazards modelling identified baseline factors that predicted events and the independent effect of events up to day 7 on poor stroke outcome at 3 months in patients alive at day 7, after correcting for prognostic factors. Higher baseline National Institute of Health Stroke Scale (NIHSS) and age, male gender, history of diabetes and stroke subtype predicted pneumonia, which occurred in 13.6% of patients. Female gender and higher baseline NIHSS and age predicted UTI, which occurred in 17.2% of patients. Pneumonia was associated with poor outcome by mortality (hazard ratio, 2.2; 95% confidence interval, 1.5-3.3), Barthel index (

Original languageEnglish
Pages (from-to)49-53
Number of pages5
JournalEuropean Journal of Neurology
Volume11
Issue number1
Publication statusPublished - Jan 2004

Keywords

  • ischaemic stroke
  • pneumonia
  • urinary tract infection
  • OXIDE SYNTHASE GENE
  • BRAIN-INJURY
  • COMPLICATIONS
  • MICE

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