Poly(A)-binding protein (PABP): a common viral target

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Abstract

Cytoplasmic PABP [poly(A)-binding protein] is a multifunctional protein with well-studied roles ill mRNA translation and stability. Ill the present review, we examine recent evidence that the activity of PABP is altered during infection with it wide range of viruses, bringing about changes ill its stability, complex formation and intracellular localization. Targeting of PABP by both RNA and DNA viruses highlights the role of PABP as a central regulator of gene expression.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalBiochemical Journal
Volume426
Issue number1
Early online date27 Jan 2010
DOIs
Publication statusPublished - 2010

Keywords

  • host cell shut-off
  • poly(A)-binding protein (PABP)
  • RNA-binding protein
  • translational activation and/or repression
  • translation initiation
  • virus

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