Poly(A)-binding protein (PABP): a common viral target

Richard W P Smith; Nicola K Gray

doi:10.1042/BJ20091571

Poly(A)-binding protein (PABP): a common viral target

Richard W P Smith, Nicola K Gray

Deanery of Clinical Sciences

Research output: Contribution to journal › Literature review › peer-review

Abstract

Cytoplasmic PABP [poly(A)-binding protein] is a multifunctional protein with well-studied roles ill mRNA translation and stability. Ill the present review, we examine recent evidence that the activity of PABP is altered during infection with it wide range of viruses, bringing about changes ill its stability, complex formation and intracellular localization. Targeting of PABP by both RNA and DNA viruses highlights the role of PABP as a central regulator of gene expression.

Original language	English
Pages (from-to)	1-12
Number of pages	12
Journal	Biochemical Journal
Volume	426
Issue number	1
Early online date	27 Jan 2010
DOIs	https://doi.org/10.1042/BJ20091571
Publication status	Published - 2010

Keywords / Materials (for Non-textual outputs)

host cell shut-off
poly(A)-binding protein (PABP)
RNA-binding protein
translational activation and/or repression
translation initiation
virus

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10.1042/BJ20091571

http://www.biochemj.org/bj/426/bj4260001.htm

Cite this

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abstract = "Cytoplasmic PABP [poly(A)-binding protein] is a multifunctional protein with well-studied roles ill mRNA translation and stability. Ill the present review, we examine recent evidence that the activity of PABP is altered during infection with it wide range of viruses, bringing about changes ill its stability, complex formation and intracellular localization. Targeting of PABP by both RNA and DNA viruses highlights the role of PABP as a central regulator of gene expression.",

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AB - Cytoplasmic PABP [poly(A)-binding protein] is a multifunctional protein with well-studied roles ill mRNA translation and stability. Ill the present review, we examine recent evidence that the activity of PABP is altered during infection with it wide range of viruses, bringing about changes ill its stability, complex formation and intracellular localization. Targeting of PABP by both RNA and DNA viruses highlights the role of PABP as a central regulator of gene expression.

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KW - translational activation and/or repression

KW - translation initiation

KW - virus

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Poly(A)-binding protein (PABP): a common viral target

Abstract

Keywords / Materials (for Non-textual outputs)

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