Polyclonal origin of colonic adenomas in an XO/XY patient with FAP

M R Novelli, J A Williamson, I P Tomlinson, G Elia, S V Hodgson, I C Talbot, W F Bodmer, N A Wright

Research output: Contribution to journalArticlepeer-review


It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examined directly by in situ hybridization with Y chromosome probes. In this patient, the crypts of the small and large intestine were clonal, but at least 76 percent of the microadenomas were polyclonal in origin.

Original languageEnglish
Pages (from-to)1187-90
Number of pages4
JournalScience (New York, N.Y.)
Issue number5265
Publication statusPublished - 24 May 1996


  • Adenomatous Polyposis Coli/genetics
  • Adult
  • Clone Cells
  • Colon/pathology
  • DNA Probes
  • Genotype
  • Humans
  • Ileum/pathology
  • In Situ Hybridization
  • In Situ Hybridization, Fluorescence
  • Intestinal Mucosa/pathology
  • Karyotyping
  • Male
  • Mosaicism
  • Phenotype
  • Y Chromosome


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