Polygenic Risk for Alzheimer's Disease is not Associated with Cognitive Ability or Cognitive Aging in Non-Demented Older People

Sarah E Harris; Gail Davies; Michelle Luciano; Antony Payton; Helen C Fox; Paul Haggarty; William Ollier; Michael Horan; David J Porteous; John M Starr; Lawrence J Whalley; Neil Pendleton; Ian J Deary

doi:10.3233/JAD-131058

Polygenic Risk for Alzheimer's Disease is not Associated with Cognitive Ability or Cognitive Aging in Non-Demented Older People

Sarah E Harris, Gail Davies, Michelle Luciano, Antony Payton, Helen C Fox, Paul Haggarty, William Ollier, Michael Horan, David J Porteous, John M Starr, Lawrence J Whalley, Neil Pendleton, Ian J Deary

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Abstract / Description of output

Alzheimer's disease (AD) and non-pathological cognitive aging have phenotypic similarities which may be influenced by an overlapping set of genetic variants. Genome-wide complex trait analysis estimates that common genetic variants account for about 24% of the variation contributing to liability for AD. It is also estimated that 24% of the variance of non-pathological cognitive aging is accounted for by common single nucleotide polymorphisms. However, although the APOE locus is associated with both AD and cognitive aging, it is not known to what extent other common genetic variants, with smaller effect sizes that influence both, overlap. We test the hypothesis that polygenic risk for AD is associated with cognitive ability and cognitive change in about 3,000 non-demented older people (Cognitive Ageing Genetics England and Scotland-CAGES-consortium). We found no significant association of polygenic risk for AD with cognitive ability or cognitive change in CAGES, indicating that the genetic etiologies of AD and non-pathological cognitive decline differ.

Original language	English
Pages (from-to)	565-574
Number of pages	10
Journal	Journal of Alzheimer's Disease
Volume	39
Issue number	3
Early online date	18 Nov 2013
DOIs	https://doi.org/10.3233/JAD-131058
Publication status	Published - 2014

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© Harris, S. E., Davies, G., Luciano, M., Payton, A., Fox, H. C., Haggarty, P., ... Deary, I. J. (2014). Polygenic Risk for Alzheimer's Disease is not Associated with Cognitive Ability or Cognitive Aging in Non-Demented Older People. Journal of Alzheimer's disease : JAD, 39(3), 565-574. 10.3233/JAD-131058
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Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.
Maclullich, A.
1/09/13 → 31/08/19
Project: Research
RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I., Gale, C., Holmes, M., Logie, P., Maclullich, A., Porteous, D., Seckl, J., Starr, J., Wardlaw, J. & Okely, J.
1/09/13 → 31/08/19
Project: Research
Disconnected Mind [Phase 2]
Wardlaw, J.
UK-based charities
1/01/11 → 31/03/16
Project: Research

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Harris, S. E., Davies, G., Luciano, M., Payton, A., Fox, H. C., Haggarty, P., Ollier, W., Horan, M., Porteous, D. J., Starr, J. M., Whalley, L. J., Pendleton, N., & Deary, I. J. (2014). Polygenic Risk for Alzheimer's Disease is not Associated with Cognitive Ability or Cognitive Aging in Non-Demented Older People. Journal of Alzheimer's Disease, 39(3), 565-574. https://doi.org/10.3233/JAD-131058

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title = "Polygenic Risk for Alzheimer's Disease is not Associated with Cognitive Ability or Cognitive Aging in Non-Demented Older People",

abstract = "Alzheimer's disease (AD) and non-pathological cognitive aging have phenotypic similarities which may be influenced by an overlapping set of genetic variants. Genome-wide complex trait analysis estimates that common genetic variants account for about 24% of the variation contributing to liability for AD. It is also estimated that 24% of the variance of non-pathological cognitive aging is accounted for by common single nucleotide polymorphisms. However, although the APOE locus is associated with both AD and cognitive aging, it is not known to what extent other common genetic variants, with smaller effect sizes that influence both, overlap. We test the hypothesis that polygenic risk for AD is associated with cognitive ability and cognitive change in about 3,000 non-demented older people (Cognitive Ageing Genetics England and Scotland-CAGES-consortium). We found no significant association of polygenic risk for AD with cognitive ability or cognitive change in CAGES, indicating that the genetic etiologies of AD and non-pathological cognitive decline differ.",

author = "Harris, {Sarah E} and Gail Davies and Michelle Luciano and Antony Payton and Fox, {Helen C} and Paul Haggarty and William Ollier and Michael Horan and Porteous, {David J} and Starr, {John M} and Whalley, {Lawrence J} and Neil Pendleton and Deary, {Ian J}",

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Harris, SE , Davies, G , Luciano, M, Payton, A, Fox, HC, Haggarty, P, Ollier, W, Horan, M, Porteous, DJ, Starr, JM, Whalley, LJ, Pendleton, N & Deary, IJ 2014, 'Polygenic Risk for Alzheimer's Disease is not Associated with Cognitive Ability or Cognitive Aging in Non-Demented Older People', Journal of Alzheimer's Disease, vol. 39, no. 3, pp. 565-574. https://doi.org/10.3233/JAD-131058

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T1 - Polygenic Risk for Alzheimer's Disease is not Associated with Cognitive Ability or Cognitive Aging in Non-Demented Older People

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AU - Davies, Gail

AU - Luciano, Michelle

AU - Payton, Antony

AU - Fox, Helen C

AU - Haggarty, Paul

AU - Ollier, William

AU - Horan, Michael

AU - Porteous, David J

AU - Starr, John M

AU - Whalley, Lawrence J

AU - Pendleton, Neil

AU - Deary, Ian J

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AB - Alzheimer's disease (AD) and non-pathological cognitive aging have phenotypic similarities which may be influenced by an overlapping set of genetic variants. Genome-wide complex trait analysis estimates that common genetic variants account for about 24% of the variation contributing to liability for AD. It is also estimated that 24% of the variance of non-pathological cognitive aging is accounted for by common single nucleotide polymorphisms. However, although the APOE locus is associated with both AD and cognitive aging, it is not known to what extent other common genetic variants, with smaller effect sizes that influence both, overlap. We test the hypothesis that polygenic risk for AD is associated with cognitive ability and cognitive change in about 3,000 non-demented older people (Cognitive Ageing Genetics England and Scotland-CAGES-consortium). We found no significant association of polygenic risk for AD with cognitive ability or cognitive change in CAGES, indicating that the genetic etiologies of AD and non-pathological cognitive decline differ.

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Polygenic Risk for Alzheimer's Disease is not Associated with Cognitive Ability or Cognitive Aging in Non-Demented Older People

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Projects

Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.

Disconnected Mind [Phase 2]

Cite this