Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy in vitro

Cinzia Ingallina, Pedro M Costa, Francesca Ghirga, Rebecca Klippstein, Julie T Wang, Simone Berardozzi, Naomi Hodgins, Paola Infante, Steven M Pollard, Bruno Botta, Khuloud T Al-Jamal

Research output: Contribution to journalArticlepeer-review

Abstract

AIM: With the purpose of delivering high doses of glabrescione B (GlaB) to solid tumors after systemic administration, long-circulating GlaB-loaded oil-cored polymeric nanocapsules (NC-GlaB) were formulated.

MATERIALS & METHODS: Synthesis of GlaB and its encapsulation in nanocapsules (NCs) was performed. Empty and GlaB-loaded NCs were assessed for their physico-chemical properties, in vitro cytotoxicity and in vivo biodistribution.

RESULTS: GlaB was efficiently loaded into NCs (∽90%), which were small (∽160 nm), homogeneous and stable upon storage. Further, GlaB and NC-GlaB demonstrated specific activities against the cancer stem cells. Preliminary studies in tumor-bearing mice supported the ability of NC to accumulate in pancreatic tumors.

CONCLUSION: This study provides early evidence that NC-GlaB has the potential to be utilized in a preclinical setting and justifies the need to perform therapeutic experiments in mice.

Original languageEnglish
Pages (from-to)711-728
Number of pages18
JournalNanomedicine
Volume12
Issue number7
Early online date21 Mar 2017
DOIs
Publication statusPublished - Apr 2017

Keywords

  • Journal Article

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