Polymorphism of a polymer precursor: metastable glycolide polymorph recovered via large scale high-pressure experiments

Ian B. Hutchison; Amit Delori; Xiao Wang; Konstantin V. Kamenev; Andrew J. Urquhart; Iain D. H. Oswald

doi:10.1039/c5ce00119f

Polymorphism of a polymer precursor: metastable glycolide polymorph recovered via large scale high-pressure experiments

Ian B. Hutchison^*, Amit Delori, Xiao Wang, Konstantin V. Kamenev, Andrew J. Urquhart, Iain D. H. Oswald

^*Corresponding author for this work

School of Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

A novel polymorph of glycolide, the precursor to polyglycolic acid, has been observed at 0.6 GPa. Large scale high-pressure production has been performed and the seeds successfully used to aid crystallisation of the polymorph at ambient pressure. PIXEL calculations confirm the metastable nature of the polymorph. Subsequent experiments show that, whilst initially stable for 12 days, this may be a case of disappearing polymorphism.

Original language	English
Pages (from-to)	1778-1782
Number of pages	5
Journal	CrystEngComm
Volume	17
Issue number	8
DOIs	https://doi.org/10.1039/c5ce00119f
Publication status	Published - 2015

Keywords / Materials (for Non-textual outputs)

ACRYLIC-ACID
DIFFRACTION
SUTURES
ANVIL
CELL

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10.1039/c5ce00119f

C5CE00119FAccepted author manuscript, 1.01 MB

New Electronic Materials from Extreme Conditions
Attfield, P., Huxley, A. & Kamenev, K.
EPSRC
29/03/12 → 28/09/17
Project: Research

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title = "Polymorphism of a polymer precursor: metastable glycolide polymorph recovered via large scale high-pressure experiments",

abstract = "A novel polymorph of glycolide, the precursor to polyglycolic acid, has been observed at 0.6 GPa. Large scale high-pressure production has been performed and the seeds successfully used to aid crystallisation of the polymorph at ambient pressure. PIXEL calculations confirm the metastable nature of the polymorph. Subsequent experiments show that, whilst initially stable for 12 days, this may be a case of disappearing polymorphism.",

keywords = "ACRYLIC-ACID, DIFFRACTION, SUTURES, ANVIL, CELL",

author = "Hutchison, {Ian B.} and Amit Delori and Xiao Wang and Kamenev, {Konstantin V.} and Urquhart, {Andrew J.} and Oswald, {Iain D. H.}",

year = "2015",

doi = "10.1039/c5ce00119f",

language = "English",

volume = "17",

pages = "1778--1782",

journal = "CrystEngComm",

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publisher = "Royal Society of Chemistry",

number = "8",

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TY - JOUR

T1 - Polymorphism of a polymer precursor

T2 - metastable glycolide polymorph recovered via large scale high-pressure experiments

AU - Hutchison, Ian B.

AU - Delori, Amit

AU - Wang, Xiao

AU - Kamenev, Konstantin V.

AU - Urquhart, Andrew J.

AU - Oswald, Iain D. H.

PY - 2015

Y1 - 2015

N2 - A novel polymorph of glycolide, the precursor to polyglycolic acid, has been observed at 0.6 GPa. Large scale high-pressure production has been performed and the seeds successfully used to aid crystallisation of the polymorph at ambient pressure. PIXEL calculations confirm the metastable nature of the polymorph. Subsequent experiments show that, whilst initially stable for 12 days, this may be a case of disappearing polymorphism.

AB - A novel polymorph of glycolide, the precursor to polyglycolic acid, has been observed at 0.6 GPa. Large scale high-pressure production has been performed and the seeds successfully used to aid crystallisation of the polymorph at ambient pressure. PIXEL calculations confirm the metastable nature of the polymorph. Subsequent experiments show that, whilst initially stable for 12 days, this may be a case of disappearing polymorphism.

KW - ACRYLIC-ACID

KW - DIFFRACTION

KW - SUTURES

KW - ANVIL

KW - CELL

U2 - 10.1039/c5ce00119f

DO - 10.1039/c5ce00119f

M3 - Article

SN - 1466-8033

VL - 17

SP - 1778

EP - 1782

JO - CrystEngComm

JF - CrystEngComm

IS - 8

ER -

Polymorphism of a polymer precursor: metastable glycolide polymorph recovered via large scale high-pressure experiments

Abstract

Keywords / Materials (for Non-textual outputs)

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