Polymorphisms of the prion protein gene coding region in born-after-the-reinforced-ban (BARB) bovine spongiform encephalopathy cattle in Great Britain

G.C. Saunders, P.C. Griffiths, S. Cawthraw, A.C. Tout, P. Wiener, John Woolliams, J.L. Williams, O. Windl

Research output: Contribution to journalArticlepeer-review

Abstract

Polymorphisms of the prion protein gene are associated with differing susceptibilities to transmissible spongiform encephalopathy diseases, as shown for variant Creutzfeldt-Jakob disease in humans and scrapie in sheep, but not yet in cattle. Imposition of control measures in the UK, including a reinforced ruminant feed ban in 1996, has led to a reduction in the incidence of bovine spongiform encephalopathy (BSE). BSE-affected cattle born after 1996 in Great Britain have been termed born-after-the-reinforced-ban (BARB) cases. In this study, the PrP gene coding region from 100 BARB BSE cases and 66 matched healthy-control cattle was sequenced to investigate whether this would reveal a genetic basis to their origin. Polymorphisms identified were not found to be associated with increased susceptibility to BSE in the BARB cases. Analysis of BARB cases grouped either by clinical status or by whether they formed an isolated or clustered case was also undertaken, but differences were not found to be significant.
Original languageUndefined/Unknown
Pages (from-to)1374-1378
Number of pages5
JournalJournal of General Virology
Volume88
Issue number4
Publication statusPublished - 2007

Keywords

  • prp gene bse sequence prnp

Cite this