Polyurethane: Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare Mater. 12/2015)

Baltasar Lucendo Villarin; Kate Cameron; Dagmara Szkolnicka; Hassan Rashidi; Nicola Bates; Susan J Kimber; Oliver Flint; Stuart J Forbes; John P Iredale; Mark Bradley; David C Hay

doi:10.1002/adhm.201570072

Polyurethane: Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare Mater. 12/2015)

Baltasar Lucendo Villarin, Kate Cameron, Dagmara Szkolnicka, Hassan Rashidi, Nicola Bates, Susan J Kimber, Oliver Flint, Stuart J Forbes, John P Iredale, Mark Bradley, David C Hay

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

One major obstacle to the routine deployment of stem cell-derived cells is their instability in culture. On page 1820 David C. Hay and co-workers describe the use of a synthetic polymer surface. The image shows stem cell-derived hepatocytes replated on this polyurethane surface. Importantly the cells express Zonal Occludin (green stain) at the cell surface, which indicates that the cells display elements of polarization. The blue stain is DAPI, which demarks the nucleus.

Original language	English
Pages (from-to)	1819
Journal	Advanced Healthcare Materials
Volume	4
Issue number	12
DOIs	https://doi.org/10.1002/adhm.201570072
Publication status	Published - Aug 2015

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Villarin, B. L., Cameron, K., Szkolnicka, D., Rashidi, H., Bates, N., Kimber, S. J., Flint, O., Forbes, S. J., Iredale, J. P., Bradley, M., & Hay, D. C. (2015). Polyurethane: Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare Mater. 12/2015). Advanced Healthcare Materials, 4(12), 1819. https://doi.org/10.1002/adhm.201570072

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title = "Polyurethane: Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare Mater. 12/2015)",

abstract = "One major obstacle to the routine deployment of stem cell-derived cells is their instability in culture. On page 1820 David C. Hay and co-workers describe the use of a synthetic polymer surface. The image shows stem cell-derived hepatocytes replated on this polyurethane surface. Importantly the cells express Zonal Occludin (green stain) at the cell surface, which indicates that the cells display elements of polarization. The blue stain is DAPI, which demarks the nucleus.",

author = "Villarin, {Baltasar Lucendo} and Kate Cameron and Dagmara Szkolnicka and Hassan Rashidi and Nicola Bates and Kimber, {Susan J} and Oliver Flint and Forbes, {Stuart J} and Iredale, {John P} and Mark Bradley and Hay, {David C}",

note = "{\textcopyright} 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2015",

month = aug,

doi = "10.1002/adhm.201570072",

language = "English",

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Villarin, BL, Cameron, K, Szkolnicka, D, Rashidi, H, Bates, N, Kimber, SJ, Flint, O, Forbes, SJ, Iredale, JP, Bradley, M & Hay, DC 2015, 'Polyurethane: Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare Mater. 12/2015)', Advanced Healthcare Materials, vol. 4, no. 12, pp. 1819. https://doi.org/10.1002/adhm.201570072

Polyurethane: Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare Mater. 12/2015). / Villarin, Baltasar Lucendo; Cameron, Kate; Szkolnicka, Dagmara et al.
In: Advanced Healthcare Materials, Vol. 4, No. 12, 08.2015, p. 1819.

Research output: Contribution to journal › Article › peer-review

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T2 - Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare Mater. 12/2015)

AU - Villarin, Baltasar Lucendo

AU - Cameron, Kate

AU - Szkolnicka, Dagmara

AU - Rashidi, Hassan

AU - Bates, Nicola

AU - Kimber, Susan J

AU - Flint, Oliver

AU - Forbes, Stuart J

AU - Iredale, John P

AU - Bradley, Mark

AU - Hay, David C

PY - 2015/8

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AB - One major obstacle to the routine deployment of stem cell-derived cells is their instability in culture. On page 1820 David C. Hay and co-workers describe the use of a synthetic polymer surface. The image shows stem cell-derived hepatocytes replated on this polyurethane surface. Importantly the cells express Zonal Occludin (green stain) at the cell surface, which indicates that the cells display elements of polarization. The blue stain is DAPI, which demarks the nucleus.

U2 - 10.1002/adhm.201570072

DO - 10.1002/adhm.201570072

M3 - Article

C2 - 26308957

SN - 2192-2640

VL - 4

SP - 1819

JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

IS - 12

ER -