Population genomics reveals the origin and asexual evolution of human infective trypanosomes

William Weir, Paul Capewell, Bernardo Foth, Caroline Clucas, Andrew Pountain, Pieter Steketee, Nicola Veitch, Mathurin Koffi, Thierry De Meeûs, Jacques Kaboré, Mamadou Camara, Anneli Cooper, Andy Tait, Vincent Jamonneau, Bruno Bucheton, Matt Berriman, Annette MacLeod

Research output: Contribution to journalArticlepeer-review

Abstract

Evolutionary theory predicts that the lack of recombination and chromosomal re-assortment in strictly asexual organisms results in homologous chromosomes irreversibly accumulating mutations and thus evolving independently of each other, a phenomenon termed the Meselson effect. We apply a population genomics approach to examine this effect in an important human pathogen, Trypanosoma brucei gambiense. We determine that T.b. gambiense is evolving strictly asexually and is derived from a single progenitor, which emerged within the last 10,000 years. We demonstrate the Meselson effect for the first time at the genome-wide level in any organism and show large regions of loss of heterozygosity, which we hypothesise to be a short-term compensatory mechanism for counteracting deleterious mutations. Our study sheds new light on the genomic and evolutionary consequences of strict asexuality, which this pathogen uses as it exploits a new biological niche, the human population.

Original languageEnglish
JournaleLIFE
Volume5
DOIs
Publication statusPublished - 26 Jan 2016

Keywords

  • Evolution, Molecular
  • Humans
  • Metagenomics
  • Mutation
  • Reproduction, Asexual
  • Trypanosoma brucei gambiense/genetics
  • Trypanosomiasis/parasitology

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