Porcine alpha-1-antitrypsin (PI): cDNA sequence, polymorphism and assignment to chromosome 7q2.4- > q2.6

A L Archibald, S Couperwhite, C H Mellink, Y Lahbib-Mansais, J Gellin

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

A cDNA clone encoding the complete coding sequence for porcine alpha-1-antitrypsin (or alpha 1-protease inhibitor, PI) was isolated and its DNA sequence determined. The cDNA is assumed to encode alpha-1-antitrypsin on the basis of its sequence similarity to the corresponding cDNAs for human, baboon, rat, mouse, sheep and cow. The porcine cDNA clone was used in conjunction with BamHI, KpnI, MspI, SacI, TaqI and XbaI to develop restriction fragment length polymorphism-based genetic markers for linkage mapping in pigs. The cDNA has also been used to map the porcine PI locus to chromosome 7q2.4- > q2.6 by radioactive in situ hybridization. Thus, the PI locus has been added to the developing physical and genetic maps of the porcine genome.
Original languageEnglish
Pages (from-to)85-9
Number of pages5
JournalAnimal Genetics
Issue number2
Publication statusPublished - Apr 1996

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Chromosome Mapping
  • Cloning, Molecular
  • DNA, Complementary
  • Molecular Sequence Data
  • Polymorphism, Restriction Fragment Length
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid
  • Swine
  • alpha 1-Antitrypsin


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