Porcine circovirus type 2 (PCV-2) coinfections in US field cases of postweaning multisystemic wasting syndrome (PMWS)

F.J. Pallarés, P.G. Halbur, T. Opriessnig, S.D. Sorden, D. Villar, B.H. Janke, M.J. Yaeger, D.J. Larson, K.J. Schwartz, K.J. Yoon, L.J. Hoffman

Research output: Contribution to journalArticlepeer-review

Abstract

The prevalence of different pathogens detected in combination with porcine circovirus type 2 (PCV-2) was studied retrospectively in field cases of postweaning multisystemic wasting syndrome (PMWS) diagnosed at the Iowa State University Veterinary Diagnostic Laboratory, Ames, Iowa, between January 2000, and September 2001. The presence of PCV-2 antigen in lymphoid tissues and/or lung, demonstrated by immunohistochemistry, together with moderate to severe lymphoid depletion and/or granulomatous lymphadenitis, was used as the criteria for the diagnosis of PMWS. A total of 484 cases fulfilled these criteria. Most of the cases (294/369) of PMWS occurred in pigs between the ages of 8 and 18 weeks, with a peak at 10 weeks of age. Porcine reproductive and respiratory syndrome virus was detected in 51.9% of the cases, Mycoplasma hyopneumoniae in 35.5%, bacterial septicemia in 14.0%, bacterial pneumonia in 7.6%, swine influenza virus in 5.4%, and PCV-2 alone in 1.9%. In cases with bacterial septicemia the most frequently isolated pathogen was Streptoccocus suis. In cases with bacterial pneumonia, Pasteurella multocida was the most prevalent.
Original languageEnglish
Pages (from-to)515-519
Number of pages5
JournalJournal of Veterinary Diagnostic Investigation
Volume14
Issue number6
DOIs
Publication statusPublished - 1 Nov 2002

Keywords

  • Animals
  • Animals, Newborn
  • Antigens, Viral/analysis
  • Circoviridae Infections/complications
  • Circoviridae Infections/veterinary
  • Circovirus/isolation & purification
  • Circovirus/pathogenicity
  • Comorbidity
  • Mycoplasma Infections/complications
  • Mycoplasma Infections/veterinary
  • Pasteurella Infections/complications
  • Pasteurella Infections/veterinary
  • Pasteurella multocida/pathogenicity
  • Porcine Reproductive and Respiratory Syndrome/pathology
  • Retrospective Studies
  • Sepsis/complications
  • Sepsis/veterinary
  • Swine
  • Swine Diseases/pathology
  • Swine Diseases/virology
  • Wasting Syndrome/veterinary
  • Wasting Syndrome/virology
  • Weaning

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