Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16

Nicole Soranzo, Bernd Bufe, Pardis C Sabeti, James F Wilson, Michael E Weale, Richard Marguerie, Wolfgang Meyerhof, David B Goldstein

Research output: Contribution to journalArticlepeer-review

Abstract

During periods of human expansion into new environments, recognition of bitter natural toxins through taste may have conferred an important selective advantage. The G protein-coupled receptor encoded by TAS2R16 mediates response to salicin, amygdalin, and many bitter beta-glucopyranosides. beta-glucopyranosides are ubiquitous in nature, with many having a highly toxic cyanogenic activity.
Original languageEnglish
Pages (from-to)1257-65
Number of pages9
JournalCurrent biology : CB
Volume15
Issue number14
DOIs
Publication statusPublished - 2005

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