Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16

Nicole Soranzo; Bernd Bufe; Pardis C Sabeti; James F Wilson; Michael E Weale; Richard Marguerie; Wolfgang Meyerhof; David B Goldstein

doi:10.1016/j.cub.2005.06.042

Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16

Nicole Soranzo, Bernd Bufe, Pardis C Sabeti, James F Wilson, Michael E Weale, Richard Marguerie, Wolfgang Meyerhof, David B Goldstein

School of Regeneration and Repair

Research output: Contribution to journal › Article › peer-review

Abstract

During periods of human expansion into new environments, recognition of bitter natural toxins through taste may have conferred an important selective advantage. The G protein-coupled receptor encoded by TAS2R16 mediates response to salicin, amygdalin, and many bitter beta-glucopyranosides. beta-glucopyranosides are ubiquitous in nature, with many having a highly toxic cyanogenic activity.

Original language	English
Pages (from-to)	1257-65
Number of pages	9
Journal	Current biology : CB
Volume	15
Issue number	14
DOIs	https://doi.org/10.1016/j.cub.2005.06.042
Publication status	Published - 2005

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title = "Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16",

abstract = "During periods of human expansion into new environments, recognition of bitter natural toxins through taste may have conferred an important selective advantage. The G protein-coupled receptor encoded by TAS2R16 mediates response to salicin, amygdalin, and many bitter beta-glucopyranosides. beta-glucopyranosides are ubiquitous in nature, with many having a highly toxic cyanogenic activity.",

author = "Nicole Soranzo and Bernd Bufe and Sabeti, \{Pardis C\} and Wilson, \{James F\} and Weale, \{Michael E\} and Richard Marguerie and Wolfgang Meyerhof and Goldstein, \{David B\}",

year = "2005",

doi = "10.1016/j.cub.2005.06.042",

language = "English",

volume = "15",

pages = "1257--65",

journal = "Current biology : CB",

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T1 - Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16

AU - Soranzo, Nicole

AU - Bufe, Bernd

AU - Sabeti, Pardis C

AU - Wilson, James F

AU - Weale, Michael E

AU - Marguerie, Richard

AU - Meyerhof, Wolfgang

AU - Goldstein, David B

PY - 2005

Y1 - 2005

N2 - During periods of human expansion into new environments, recognition of bitter natural toxins through taste may have conferred an important selective advantage. The G protein-coupled receptor encoded by TAS2R16 mediates response to salicin, amygdalin, and many bitter beta-glucopyranosides. beta-glucopyranosides are ubiquitous in nature, with many having a highly toxic cyanogenic activity.

AB - During periods of human expansion into new environments, recognition of bitter natural toxins through taste may have conferred an important selective advantage. The G protein-coupled receptor encoded by TAS2R16 mediates response to salicin, amygdalin, and many bitter beta-glucopyranosides. beta-glucopyranosides are ubiquitous in nature, with many having a highly toxic cyanogenic activity.

U2 - 10.1016/j.cub.2005.06.042

DO - 10.1016/j.cub.2005.06.042

M3 - Article

C2 - 16051168

SN - 0960-9822

VL - 15

SP - 1257

EP - 1265

JO - Current biology : CB

JF - Current biology : CB

IS - 14

ER -

Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16

Abstract

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