Post-mortem dissection of COVID-19: a pathogenic role for macrophages?

Prasad P Velu; Christopher D Lucas; Andrew Conway Morris

doi:10.1007/s00134-021-06509-9

Post-mortem dissection of COVID-19: a pathogenic role for macrophages?

Prasad P Velu, Christopher D Lucas, Andrew Conway Morris

Research output: Contribution to journal › Editorial › peer-review

Abstract

Acute respiratory failure is the leading cause of death in severe COVID-19. By combining rapid tissue sampling at autopsy with high dimensional analyses, including measurement of immune cells, proteins and RNA, unparalleled insights into the mechanisms of dysregulated inflammation in COVID-19 have been obtained1–4. Here we summarise some of the conceptual advances revealed by post-mortem studies of severe COVID-19, and make particular reference to the apparent dominance of macrophages, how this may relate to disease pathophysiology, and the opportunities for targeted therapeutic intervention.

Original language	English
Journal	Intensive Care Medicine
Early online date	1 Sept 2021
DOIs	https://doi.org/10.1007/s00134-021-06509-9
Publication status	E-pub ahead of print - 1 Sept 2021

Access to Document

10.1007/s00134-021-06509-9

Velu 2021 ICM Editorial
Author's peer reviewed manuscript as accepted for publication.
Accepted author manuscript, 63.6 KB

https://link.springer.com/content/pdf/10.1007/s00134-021-06509-9.pdf

Inflammation in Covid-19: Exploration of Critical Aspects of Pathogenesis -ICECAP extension
Lucas, C. (Principal Investigator) & Dorward, D. (Co-investigator)
UK central government bodies/local authorities, health and hospital authorities
4/08/20 → 3/11/21
Project: Research
Macrophage-epithelial communication promotes lung repair after injury
Lucas, C. (Principal Investigator)
UK-based charities
3/07/17 → 4/08/22
Project: Research

Cite this

@article{49d86028fb5c4c729d061ac89eb2ba91,

title = "Post-mortem dissection of COVID-19: a pathogenic role for macrophages?",

abstract = "Acute respiratory failure is the leading cause of death in severe COVID-19. By combining rapid tissue sampling at autopsy with high dimensional analyses, including measurement of immune cells, proteins and RNA, unparalleled insights into the mechanisms of dysregulated inflammation in COVID-19 have been obtained1–4. Here we summarise some of the conceptual advances revealed by post-mortem studies of severe COVID-19, and make particular reference to the apparent dominance of macrophages, how this may relate to disease pathophysiology, and the opportunities for targeted therapeutic intervention.",

author = "Velu, {Prasad P} and Lucas, {Christopher D} and {Conway Morris}, Andrew",

year = "2021",

month = sep,

day = "1",

doi = "10.1007/s00134-021-06509-9",

language = "English",

journal = "Intensive Care Medicine",