Post-operative arm morbidity and quality of life. Results of the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early breast cancer

Anne Fleissig; Lesley J Fallowfield; Carolyn I Langridge; Leigh Johnson; Robert G Newcombe; J Michael Dixon; Mark Kissin; Robert E Mansel

doi:10.1007/s10549-005-9025-7

Post-operative arm morbidity and quality of life. Results of the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early breast cancer

Anne Fleissig, Lesley J Fallowfield, Carolyn I Langridge, Leigh Johnson, Robert G Newcombe, J Michael Dixon, Mark Kissin, Robert E Mansel

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

This study is the first large prospective RCT of sentinel node biopsy (SNB) compared with standard axillary treatment (level I-III axillary lymph node dissection or four node sampling), which includes comprehensive and repeated quality of life (QOL) assessments over 18 months. Patients (n = 829) completed the Functional Assessment of Cancer Therapy - Breast (FACT-B+4) and the Spielberger State/Trait Anxiety Inventory (STAI) at baseline (pre-surgery) and at 1, 3, 6, 12, and 18 months post-surgery. There were significant differences between treatment groups favouring the SNB group throughout the 18 months assessment. Patients in the standard treatment group showed a greater decline in Trial Outcome Index (TOI) scores (physical well-being, functional well-being and breast cancer concerns subscales in FACT-B+4) and recovered more slowly than patients in the SNB group (p 0.05). For 6 months post-surgery younger patients reported less favourable QOL scores (p

Original language	English
Pages (from-to)	279-93
Number of pages	15
Journal	Breast cancer research and treatment
Volume	95
Issue number	3
DOIs	https://doi.org/10.1007/s10549-005-9025-7
Publication status	Published - Feb 2006

Keywords

Adult
Aged
Aged, 80 and over
Arm
Axilla
Breast Neoplasms
Female
Humans
Lymph Node Excision
Lymphatic Metastasis
Middle Aged
Morbidity
Postoperative Period
Quality of Life
Questionnaires
Sentinel Lymph Node Biopsy
Treatment Outcome

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Fleissig, A., Fallowfield, L. J., Langridge, C. I., Johnson, L., Newcombe, R. G., Dixon, J. M., Kissin, M., & Mansel, R. E. (2006). Post-operative arm morbidity and quality of life. Results of the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early breast cancer. Breast cancer research and treatment, 95(3), 279-93. https://doi.org/10.1007/s10549-005-9025-7

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title = "Post-operative arm morbidity and quality of life. Results of the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early breast cancer",

abstract = "This study is the first large prospective RCT of sentinel node biopsy (SNB) compared with standard axillary treatment (level I-III axillary lymph node dissection or four node sampling), which includes comprehensive and repeated quality of life (QOL) assessments over 18 months. Patients (n = 829) completed the Functional Assessment of Cancer Therapy - Breast (FACT-B+4) and the Spielberger State/Trait Anxiety Inventory (STAI) at baseline (pre-surgery) and at 1, 3, 6, 12, and 18 months post-surgery. There were significant differences between treatment groups favouring the SNB group throughout the 18 months assessment. Patients in the standard treatment group showed a greater decline in Trial Outcome Index (TOI) scores (physical well-being, functional well-being and breast cancer concerns subscales in FACT-B+4) and recovered more slowly than patients in the SNB group (p 0.05). For 6 months post-surgery younger patients reported less favourable QOL scores (p ",

keywords = "Adult, Aged, Aged, 80 and over, Arm, Axilla, Breast Neoplasms, Female, Humans, Lymph Node Excision, Lymphatic Metastasis, Middle Aged, Morbidity, Postoperative Period, Quality of Life, Questionnaires, Sentinel Lymph Node Biopsy, Treatment Outcome",

author = "Anne Fleissig and Fallowfield, {Lesley J} and Langridge, {Carolyn I} and Leigh Johnson and Newcombe, {Robert G} and Dixon, {J Michael} and Mark Kissin and Mansel, {Robert E}",

year = "2006",

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doi = "10.1007/s10549-005-9025-7",

language = "English",

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Fleissig, A, Fallowfield, LJ, Langridge, CI, Johnson, L, Newcombe, RG, Dixon, JM, Kissin, M & Mansel, RE 2006, 'Post-operative arm morbidity and quality of life. Results of the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early breast cancer', Breast cancer research and treatment, vol. 95, no. 3, pp. 279-93. https://doi.org/10.1007/s10549-005-9025-7

Post-operative arm morbidity and quality of life. Results of the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early breast cancer. / Fleissig, Anne; Fallowfield, Lesley J; Langridge, Carolyn I et al.

In: Breast cancer research and treatment, Vol. 95, No. 3, 02.2006, p. 279-93.

Research output: Contribution to journal › Article › peer-review

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T1 - Post-operative arm morbidity and quality of life. Results of the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early breast cancer

AU - Fleissig, Anne

AU - Fallowfield, Lesley J

AU - Langridge, Carolyn I

AU - Johnson, Leigh

AU - Newcombe, Robert G

AU - Dixon, J Michael

AU - Kissin, Mark

AU - Mansel, Robert E

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N2 - This study is the first large prospective RCT of sentinel node biopsy (SNB) compared with standard axillary treatment (level I-III axillary lymph node dissection or four node sampling), which includes comprehensive and repeated quality of life (QOL) assessments over 18 months. Patients (n = 829) completed the Functional Assessment of Cancer Therapy - Breast (FACT-B+4) and the Spielberger State/Trait Anxiety Inventory (STAI) at baseline (pre-surgery) and at 1, 3, 6, 12, and 18 months post-surgery. There were significant differences between treatment groups favouring the SNB group throughout the 18 months assessment. Patients in the standard treatment group showed a greater decline in Trial Outcome Index (TOI) scores (physical well-being, functional well-being and breast cancer concerns subscales in FACT-B+4) and recovered more slowly than patients in the SNB group (p 0.05). For 6 months post-surgery younger patients reported less favourable QOL scores (p

AB - This study is the first large prospective RCT of sentinel node biopsy (SNB) compared with standard axillary treatment (level I-III axillary lymph node dissection or four node sampling), which includes comprehensive and repeated quality of life (QOL) assessments over 18 months. Patients (n = 829) completed the Functional Assessment of Cancer Therapy - Breast (FACT-B+4) and the Spielberger State/Trait Anxiety Inventory (STAI) at baseline (pre-surgery) and at 1, 3, 6, 12, and 18 months post-surgery. There were significant differences between treatment groups favouring the SNB group throughout the 18 months assessment. Patients in the standard treatment group showed a greater decline in Trial Outcome Index (TOI) scores (physical well-being, functional well-being and breast cancer concerns subscales in FACT-B+4) and recovered more slowly than patients in the SNB group (p 0.05). For 6 months post-surgery younger patients reported less favourable QOL scores (p

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KW - Lymphatic Metastasis

KW - Middle Aged

KW - Morbidity

KW - Postoperative Period

KW - Quality of Life

KW - Questionnaires

KW - Sentinel Lymph Node Biopsy

KW - Treatment Outcome

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JO - Breast cancer research and treatment

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Fleissig A, Fallowfield LJ, Langridge CI, Johnson L, Newcombe RG, Dixon JM et al. Post-operative arm morbidity and quality of life. Results of the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early breast cancer. Breast cancer research and treatment. 2006 Feb;95(3):279-93. doi: 10.1007/s10549-005-9025-7