Posterior cingulate neurometabolite profiles and clinical phenotype in frontotemporal dementia

Peter Garrard, Jonathan M Schott, David G MacManus, John R Hodges, Nicholas C Fox, Adam D Waldman

Research output: Contribution to journalArticlepeer-review

Abstract

Proton magnetic resonance spectroscopy was used to compare metabolite levels from a posterior cingulate voxel in a group of patients with 2 syndromic subtypes of frontotemporal dementia (n=10) and an age and education-matched group with Alzheimer disease (n=10). Overall, frontotemporal dementia was indistinguishable from Alzheimer disease, though differences in N-acetylaspartate emerged between patients with the SD and progressive nonfluent aphasia subtypes, attributable to 2 atypical results among the latter. Such values may index cases with atrophy in posterior cortical regions presenting with progressive nonfluent aphasia.

Original languageEnglish
Pages (from-to)185-9
Number of pages5
JournalCognitive and Behavioral Neurology
Volume19
Issue number4
DOIs
Publication statusPublished - Dec 2006

Keywords

  • Aged
  • Alzheimer Disease
  • Aspartic Acid
  • Atrophy
  • Dementia
  • Diagnosis, Differential
  • Female
  • Frontal Lobe
  • Humans
  • Inositol
  • Magnetic Resonance Spectroscopy
  • Male
  • Matched-Pair Analysis
  • Middle Aged
  • Temporal Lobe
  • Comparative Study
  • Journal Article

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