Abstract
A 49-year-old woman who had previously received treatment with cytotoxic drugs for metastatic gestational trophoblastic disease (GTD) presented with a witnessed tonic-clonic seizure, headache, confusion and blindness, 6 days after the uneventful administration of a general anaesthetic and 2 months after cessation of chemotherapy. Magnetic resonance imaging showed relatively symmetrical, subcortical, white matter abnormalities, predominantly affecting the occipital, posterior temporal and parietal lobes and the cerebellum. T2-dependent abnormalities and elevated regional apparent diffusion coefficient were present in a pattern typical for posterior reversible encephalopathy syndrome (PRES). The clinical and radiological manifestations were resolved completely with supportive therapy. This case of PRES may be a late complication of gemcitabine or cisplatin therapy precipitated by a general anaesthetic, or associated electrolyte or blood pressure disturbance.
Original language | English |
---|---|
Pages (from-to) | 586-90 |
Number of pages | 5 |
Journal | Neuroradiology |
Volume | 47 |
Issue number | 8 |
DOIs | |
Publication status | Published - 5 Jul 2005 |
Keywords
- Anesthesia, General
- Antimetabolites, Antineoplastic
- Blood Pressure
- Brain
- Brain Diseases
- Deoxycytidine
- Diffusion Magnetic Resonance Imaging
- Female
- Gestational Trophoblastic Disease
- Humans
- Middle Aged
- Pregnancy
- Syndrome
- Water-Electrolyte Balance
- Case Reports
- Journal Article