Postprandial decrease in splenic volume demonstrated by magnetic resonance imaging and stereology

D Betal*, ML Hughes, N Roberts, GH Whitehouse

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to determine if the volume of the spleen changes after food intake. We applied an unbiased and efficient method for splenic volume estimation using magnetic resonance imaging (MRI) in combination with modern design stereology. MR images of the spleen were obtained for 10 healthy volunteers (five men and five women; mean age 28.9 years [range 23-35 years]) without a history of splenomegaly. The initial scans were performed in the morning after overnight fasting. Each volunteer then consumed a standard balanced meal weighing 500 g [2,360 kJ (627 kcal) energy] with 500 mi of still mineral water. Second identical MR scans were performed approximately 1 hr later. Postprandially, splenic volume decreased by an average of 6.6% (P = 0.005), probably due to increased splanchnic blood flow after food intake. Clin. Anat. 13:404-409, 2000. (C) 2000 Wiley-Liss. Inc.

Original languageEnglish
Pages (from-to)404-409
Number of pages6
JournalClinical Anatomy
Volume13
Issue number6
Publication statusPublished - 2000

Keywords

  • image analysis
  • spleen measurement
  • COMPUTED-TOMOGRAPHY
  • SPLEEN VOLUME
  • LIVER
  • SPECT
  • MEAL
  • HEMODYNAMICS
  • DOPPLER
  • DISEASE

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