This study investigates the benefit of including information on an identified major gene in the estimation of breeding values in BLUP selection programmes. Selection for a quantitative trait is controlled by polygenes and a major locus with known effect. The benefit of using the gene information obtained in the short-term was maintained in the long-term by applying a selection tool which makes use of BLUP evaluation and optimisation of genetic contributions for maximising genetic gain while restricting the rate of inbreeding. In the mixed inheritance model the selection tool, initially proposed for an infinitesimal model, was able to restrict the rate of inbreeding to the desired value and to give higher rates of response than standard truncation selection both when using and ignoring the information on the major gene. The simple use of BLUP (standard truncation selection) allowed long-term benefits from using the gene in situations where the favourable allele was recessive or additive with large effect. (C) Inra/Elsevier, Paris.
|Number of pages||19|
|Journal||Genetics Selection Evolution|
|Publication status||Published - 1999|
- major gene optimal selection BLUP selection restricted inbreeding marker-assisted selection mass selection information populations rates prediction strategies