Potential conservation of circadian clock proteins in the phylum nematoda as revealed by bioinformatic searches

Andres Romanowski, Matias Javier Garavaglia, Maria Eugenia Goya, Pablo Daniel Ghiringhelli, Diego Andres Golombek*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Although several circadian rhythms have been described in C. elegans, its molecular clock remains elusive. In this work we employed a novel bioinformatic approach, applying probabilistic methodologies, to search for circadian clock proteins of several of the best studied circadian model organisms of different taxa (Mus musculus, Drosophila melanogaster, Neurospora crassa, Arabidopsis thaliana and Synechoccocus elongatus) in the proteomes of C. elegans and other members of the phylum Nematoda. With this approach we found that the Nematoda contain proteins most related to the core and accessory proteins of the insect and mammalian clocks, which provide new insights into the nematode clock and the evolution of the circadian system.

Original languageEnglish
Article number112871
Number of pages16
JournalPLoS ONE
Issue number11
Publication statusPublished - 14 Nov 2014


  • aryl-hydrocarbon receptor
  • caenorhabditis-elegans
  • c-elegans
  • mammalian timeless
  • e-box
  • drosophila head
  • gene-expression
  • complex
  • transcription
  • feedback

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