Potential for gene editing in antiviral resistance

Douglas Pyott; Yue Fei; Attila Molnar

doi:10.1016/j.coviro.2020.04.005

Potential for gene editing in antiviral resistance

Douglas Pyott, Yue Fei, Attila Molnar

Research output: Contribution to journal › Book/Film/Article review › peer-review

Abstract / Description of output

The discovery of CRISPR/Cas systems and their subsequent application in genome modifications and in gene expression control have fundamentally changed both basic and applied research. They have already been employed to generate novel virus resistance traits either by modifying host factors in the plant genome or by directly inducing targeted virus degradation. Here we summarise the latest developments in this field and discuss the potential applications and concerns around this technology.

Original language	English
Pages (from-to)	47-52
Journal	Current Opinion in Virology
Early online date	5 Jun 2020
DOIs	https://doi.org/10.1016/j.coviro.2020.04.005
Publication status	E-pub ahead of print - 5 Jun 2020

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10.1016/j.coviro.2020.04.005Licence: Creative Commons: Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

MolnarEtalCOV2020PotentialForGeneEditingInAntiviralResistanceAccepted author manuscript, 478 KBLicence: Creative Commons: Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

Identifying and characterising the translation-associated host factor of Papaya Ringspot Virus (PRSV) and generating novel resistance alleles by genome editing
Molnar, A.
UK-based charities
1/12/17 → 31/05/21
Project: Research

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title = "Potential for gene editing in antiviral resistance",

abstract = "The discovery of CRISPR/Cas systems and their subsequent application in genome modifications and in gene expression control have fundamentally changed both basic and applied research. They have already been employed to generate novel virus resistance traits either by modifying host factors in the plant genome or by directly inducing targeted virus degradation. Here we summarise the latest developments in this field and discuss the potential applications and concerns around this technology.",

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AB - The discovery of CRISPR/Cas systems and their subsequent application in genome modifications and in gene expression control have fundamentally changed both basic and applied research. They have already been employed to generate novel virus resistance traits either by modifying host factors in the plant genome or by directly inducing targeted virus degradation. Here we summarise the latest developments in this field and discuss the potential applications and concerns around this technology.

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Potential for gene editing in antiviral resistance

Abstract / Description of output

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Projects

Identifying and characterising the translation-associated host factor of Papaya Ringspot Virus (PRSV) and generating novel resistance alleles by genome editing

Cite this