Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19

Jean Bousquet; Wienczyslawa Czarlewski; Torsten Zuberbier; Joaquim Mullol; Hubert Blain; Jean-paul Cristol; Rafael De La Torre; Nieves Pizarro Lozano; Vincent Le Moing; Anna Bedbrook; Ioana Agache; Cezmi A. Akdis; G. Walter Canonica; Alvaro A. Cruz; Alessandro Fiocchi; Joao A. Fonseca; Susana Fonseca; Bilun Gemicioğlu; Tari Haahtela; Guido Iaccarino; Juan Carlos Ivancevich; Marek Jutel; Ludger Klimek; Helga Kraxner; Piotr Kuna; Désirée E. Larenas-linnemann; Adrian Martineau; Erik Melén; Yoshitaka Okamoto; Nikolaos G. Papadopoulos; Oliver Pfaar; Frederico S. Regateiro; Jacques Reynes; Yves Rolland; Philip W. Rouadi; Boleslaw Samolinski; Aziz Sheikh; Sanna Toppila-salmi; Arunas Valiulis; Hak-jong Choi; Hyun Ju Kim; Josep M. Anto

doi:10.1159/000514204

Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19

Jean Bousquet, Wienczyslawa Czarlewski, Torsten Zuberbier, Joaquim Mullol, Hubert Blain, Jean-paul Cristol, Rafael De La Torre, Nieves Pizarro Lozano, Vincent Le Moing, Anna Bedbrook, Ioana Agache, Cezmi A. Akdis, G. Walter Canonica, Alvaro A. Cruz, Alessandro Fiocchi, Joao A. Fonseca, Susana Fonseca, Bilun Gemicioğlu, Tari Haahtela, Guido IaccarinoJuan Carlos Ivancevich, Marek Jutel, Ludger Klimek, Helga Kraxner, Piotr Kuna, Désirée E. Larenas-linnemann, Adrian Martineau, Erik Melén, Yoshitaka Okamoto, Nikolaos G. Papadopoulos, Oliver Pfaar, Frederico S. Regateiro, Jacques Reynes, Yves Rolland, Philip W. Rouadi, Boleslaw Samolinski, Aziz Sheikh, Sanna Toppila-salmi, Arunas Valiulis, Hak-jong Choi, Hyun Ju Kim, Josep M. Anto

Research output: Contribution to journal › Article › peer-review

Abstract

In this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potential
ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. TRPA1
and TRPV1 induce inflammation and play a key role in the
physiology of almost all organs. They may augment sensory
or vagal nerve discharges to evoke pain and several symptoms of COVID-19, including cough, nasal obstruction, vomiting, diarrhea, and, at least partly, sudden and severe loss of
smell and taste. TRPA1 can be activated by reactive oxygen
species and may therefore be up-regulated in COVID-19.
TRPA1 and TRPV1 channels can be activated by pungent
compounds including many nuclear factor (erythroid-derived 2) (Nrf2)-interacting foods leading to channel desensitization. Interactions between Nrf2-associated nutrients and
TRPA1/TRPV1 may be partly responsible for the severity of
some of the COVID-19 symptoms. The regulation by Nrf2 of
TRPA1/TRPV1 is still unclear, but suggested from very limited
clinical evidence. In COVID-19, it is proposed that rapid desensitization of TRAP1/TRPV1 by some ingredients in foods
could reduce symptom severity and provide new therapeutic strategies.

Original language	English
Pages (from-to)	1-15
Journal	International archives of allergy and immunology
Volume	182
Issue number	4
Early online date	10 Feb 2021
DOIs	https://doi.org/10.1159/000514204
Publication status	E-pub ahead of print - 10 Feb 2021

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Bousquet, J., Czarlewski, W., Zuberbier, T., Mullol, J., Blain, H., Cristol, J., De La Torre, R., Pizarro Lozano, N., Le Moing, V., Bedbrook, A., Agache, I., Akdis, C. A., Canonica, G. W., Cruz, A. A., Fiocchi, A., Fonseca, J. A., Fonseca, S., Gemicioğlu, B., Haahtela, T., ... Anto, J. M. (2021). Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19. International archives of allergy and immunology, 182(4), 1-15. Advance online publication. https://doi.org/10.1159/000514204

@article{e67569c2669243cfa990f89da4dd5756,

title = "Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19",

abstract = "In this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potentialankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. TRPA1and TRPV1 induce inflammation and play a key role in thephysiology of almost all organs. They may augment sensoryor vagal nerve discharges to evoke pain and several symptoms of COVID-19, including cough, nasal obstruction, vomiting, diarrhea, and, at least partly, sudden and severe loss ofsmell and taste. TRPA1 can be activated by reactive oxygenspecies and may therefore be up-regulated in COVID-19.TRPA1 and TRPV1 channels can be activated by pungentcompounds including many nuclear factor (erythroid-derived 2) (Nrf2)-interacting foods leading to channel desensitization. Interactions between Nrf2-associated nutrients andTRPA1/TRPV1 may be partly responsible for the severity ofsome of the COVID-19 symptoms. The regulation by Nrf2 ofTRPA1/TRPV1 is still unclear, but suggested from very limitedclinical evidence. In COVID-19, it is proposed that rapid desensitization of TRAP1/TRPV1 by some ingredients in foodscould reduce symptom severity and provide new therapeutic strategies.",

author = "Jean Bousquet and Wienczyslawa Czarlewski and Torsten Zuberbier and Joaquim Mullol and Hubert Blain and Jean-paul Cristol and {De La Torre}, Rafael and {Pizarro Lozano}, Nieves and {Le Moing}, Vincent and Anna Bedbrook and Ioana Agache and Akdis, {Cezmi A.} and Canonica, {G. Walter} and Cruz, {Alvaro A.} and Alessandro Fiocchi and Fonseca, {Joao A.} and Susana Fonseca and Bilun Gemicioğlu and Tari Haahtela and Guido Iaccarino and Ivancevich, {Juan Carlos} and Marek Jutel and Ludger Klimek and Helga Kraxner and Piotr Kuna and Larenas-linnemann, {D{\'e}sir{\'e}e E.} and Adrian Martineau and Erik Mel{\'e}n and Yoshitaka Okamoto and Papadopoulos, {Nikolaos G.} and Oliver Pfaar and Regateiro, {Frederico S.} and Jacques Reynes and Yves Rolland and Rouadi, {Philip W.} and Boleslaw Samolinski and Aziz Sheikh and Sanna Toppila-salmi and Arunas Valiulis and Hak-jong Choi and Kim, {Hyun Ju} and Anto, {Josep M.}",

year = "2021",

month = feb,

day = "10",

doi = "10.1159/000514204",

language = "English",

volume = "182",

pages = "1--15",

journal = "International archives of allergy and immunology",

issn = "1018-2438",

publisher = "S. Karger AG",

number = "4",

}

Bousquet, J, Czarlewski, W, Zuberbier, T, Mullol, J, Blain, H, Cristol, J, De La Torre, R, Pizarro Lozano, N, Le Moing, V, Bedbrook, A, Agache, I, Akdis, CA, Canonica, GW, Cruz, AA, Fiocchi, A, Fonseca, JA, Fonseca, S, Gemicioğlu, B, Haahtela, T, Iaccarino, G, Ivancevich, JC, Jutel, M, Klimek, L, Kraxner, H, Kuna, P, Larenas-linnemann, DE, Martineau, A, Melén, E, Okamoto, Y, Papadopoulos, NG, Pfaar, O, Regateiro, FS, Reynes, J, Rolland, Y, Rouadi, PW, Samolinski, B, Sheikh, A, Toppila-salmi, S, Valiulis, A, Choi, H, Kim, HJ & Anto, JM 2021, 'Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19', International archives of allergy and immunology, vol. 182, no. 4, pp. 1-15. https://doi.org/10.1159/000514204

TY - JOUR

T1 - Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19

AU - Bousquet, Jean

AU - Czarlewski, Wienczyslawa

AU - Zuberbier, Torsten

AU - Mullol, Joaquim

AU - Blain, Hubert

AU - Cristol, Jean-paul

AU - De La Torre, Rafael

AU - Pizarro Lozano, Nieves

AU - Le Moing, Vincent

AU - Bedbrook, Anna

AU - Agache, Ioana

AU - Akdis, Cezmi A.

AU - Canonica, G. Walter

AU - Cruz, Alvaro A.

AU - Fiocchi, Alessandro

AU - Fonseca, Joao A.

AU - Fonseca, Susana

AU - Gemicioğlu, Bilun

AU - Haahtela, Tari

AU - Iaccarino, Guido

AU - Ivancevich, Juan Carlos

AU - Jutel, Marek

AU - Klimek, Ludger

AU - Kraxner, Helga

AU - Kuna, Piotr

AU - Larenas-linnemann, Désirée E.

AU - Martineau, Adrian

AU - Melén, Erik

AU - Okamoto, Yoshitaka

AU - Papadopoulos, Nikolaos G.

AU - Pfaar, Oliver

AU - Regateiro, Frederico S.

AU - Reynes, Jacques

AU - Rolland, Yves

AU - Rouadi, Philip W.

AU - Samolinski, Boleslaw

AU - Sheikh, Aziz

AU - Toppila-salmi, Sanna

AU - Valiulis, Arunas

AU - Choi, Hak-jong

AU - Kim, Hyun Ju

AU - Anto, Josep M.

PY - 2021/2/10

Y1 - 2021/2/10

N2 - In this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potentialankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. TRPA1and TRPV1 induce inflammation and play a key role in thephysiology of almost all organs. They may augment sensoryor vagal nerve discharges to evoke pain and several symptoms of COVID-19, including cough, nasal obstruction, vomiting, diarrhea, and, at least partly, sudden and severe loss ofsmell and taste. TRPA1 can be activated by reactive oxygenspecies and may therefore be up-regulated in COVID-19.TRPA1 and TRPV1 channels can be activated by pungentcompounds including many nuclear factor (erythroid-derived 2) (Nrf2)-interacting foods leading to channel desensitization. Interactions between Nrf2-associated nutrients andTRPA1/TRPV1 may be partly responsible for the severity ofsome of the COVID-19 symptoms. The regulation by Nrf2 ofTRPA1/TRPV1 is still unclear, but suggested from very limitedclinical evidence. In COVID-19, it is proposed that rapid desensitization of TRAP1/TRPV1 by some ingredients in foodscould reduce symptom severity and provide new therapeutic strategies.

AB - In this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potentialankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. TRPA1and TRPV1 induce inflammation and play a key role in thephysiology of almost all organs. They may augment sensoryor vagal nerve discharges to evoke pain and several symptoms of COVID-19, including cough, nasal obstruction, vomiting, diarrhea, and, at least partly, sudden and severe loss ofsmell and taste. TRPA1 can be activated by reactive oxygenspecies and may therefore be up-regulated in COVID-19.TRPA1 and TRPV1 channels can be activated by pungentcompounds including many nuclear factor (erythroid-derived 2) (Nrf2)-interacting foods leading to channel desensitization. Interactions between Nrf2-associated nutrients andTRPA1/TRPV1 may be partly responsible for the severity ofsome of the COVID-19 symptoms. The regulation by Nrf2 ofTRPA1/TRPV1 is still unclear, but suggested from very limitedclinical evidence. In COVID-19, it is proposed that rapid desensitization of TRAP1/TRPV1 by some ingredients in foodscould reduce symptom severity and provide new therapeutic strategies.

U2 - 10.1159/000514204

DO - 10.1159/000514204

M3 - Article

SN - 1018-2438

VL - 182

SP - 1

EP - 15

JO - International archives of allergy and immunology

JF - International archives of allergy and immunology

IS - 4

ER -

Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19

Abstract

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