Power and sample size for cost-effectiveness analysis: fFN neonatal screening

Kathleen A. Boyd*, Andrew H. Briggs, Elisabeth Fenwick, John Norrie, Sarah Stock

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Randomised controlled trials (RCTs) which involve cost-effectiveness evaluations rarely use health economic input when undertaking sample size calculations for the trial design: however, in studies undertaken with cost-effectiveness as the primary outcome, sample size calculations should be directly related to the cost-effectiveness result rather than to the effectiveness outcome alone. This paper reports on a case in which a clinical trial design sample size and power calculations were determined with regard to cost-effectiveness using the net monetary benefit (NMB) approach to demonstrate the feasibility of sample size calculation for cost-effectiveness in a real life setting.

The proposed RCT of fetal fibronectin screening (fFN) for women with threatened pre-term labour is discussed, followed by the design of a preliminary model to inform the trial design calculation. The predictions from this pre-trial indicate potential cost-savings, but with a marginal detrimental impact on the effectiveness endpoint, neonatal morbidity. The NMB approach for cost-effectiveness is discussed and used to calculate the required sample sizes for different powers. The sample size calculations are then recalculated using a non-inferiority margin, to ensure that the NMB sample size for the trial was also sufficient to demonstrate non-inferiority for the effectiveness endpoint. Finally, a probabilistic analysis explored uncertainty in the model parameters and the impact on sample size.

Considerations of economic assessments alongside clinical trials can and should be used to guide conventional trial design. This paper demonstrates the feasibility of such calculations, whilst simultaneously highlighting limitations and demonstrating the role for economic considerations to guide non-inferiority margins. (C) 2011 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)893-901
Number of pages9
JournalContemporary Clinical Trials
Volume32
Issue number6
DOIs
Publication statusPublished - Nov 2011

Keywords

  • Cost-effectiveness
  • STATISTICAL LIFE
  • POLICY
  • HEALTH
  • CLINICAL-TRIALS
  • Sample size
  • Net monetary benefit
  • Non-inferiority
  • Study design

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