TY - JOUR
T1 - Pre-treatment choroidal thickness is not predictive of susceptibility to form-deprivation myopia in chickens
AU - Guggenheim, J. A.
AU - Chen, Y. P.
AU - Yip, E.
AU - Hayet, H.
AU - Druel, V.
AU - Wang, L.
AU - Erichsen, J. T.
AU - Tumlinson, A. R.
AU - Povazay, B.
AU - Drexler, W.
AU - Hocking, P. M.
PY - 2011
Y1 - 2011
N2 - Citation information: Guggenheim JA, Chen Y-P, Yip E, Hayet H, Druel V, Wang L, Erichsen JT, Tumlinson AR, Povazay B, Drexler W & Hocking PM. Pre-treatment choroidal thickness is not predictive of susceptibility to form-deprivation myopia in chickens. Ophthalmic Physiol Opt 2011. doi: 10.1111/j.1475-1313.2011.00827.x ABSTRACT: Purpose: Chicks developing experimentally-induced myopia show profound thinning of the choroid. We observed a wide range of choroidal thicknesses in a sample of normal chicks prior to their use in a pedigree-based study of form-deprivation myopia. Hence, we tested whether pre-treatment choroidal thickness predicted susceptibility to myopia. Methods: Retinal, choroidal and scleral thickness were measured using A-scan ultrasonography in normal White Leghorn chicks (n = 891) aged 4 days old, and again (n = 498) after 4 days of monocular form-deprivation at age 8 days of age. Refractive error was assessed by retinoscopy. Relationships between pre-treatment choroidal thickness and other variables were investigated using general linear models and variance components analysis. Results: Untreated 4 day-old male chicks had choroids approximately 10% thinner than females (p <0.001), but sex explained
AB - Citation information: Guggenheim JA, Chen Y-P, Yip E, Hayet H, Druel V, Wang L, Erichsen JT, Tumlinson AR, Povazay B, Drexler W & Hocking PM. Pre-treatment choroidal thickness is not predictive of susceptibility to form-deprivation myopia in chickens. Ophthalmic Physiol Opt 2011. doi: 10.1111/j.1475-1313.2011.00827.x ABSTRACT: Purpose: Chicks developing experimentally-induced myopia show profound thinning of the choroid. We observed a wide range of choroidal thicknesses in a sample of normal chicks prior to their use in a pedigree-based study of form-deprivation myopia. Hence, we tested whether pre-treatment choroidal thickness predicted susceptibility to myopia. Methods: Retinal, choroidal and scleral thickness were measured using A-scan ultrasonography in normal White Leghorn chicks (n = 891) aged 4 days old, and again (n = 498) after 4 days of monocular form-deprivation at age 8 days of age. Refractive error was assessed by retinoscopy. Relationships between pre-treatment choroidal thickness and other variables were investigated using general linear models and variance components analysis. Results: Untreated 4 day-old male chicks had choroids approximately 10% thinner than females (p <0.001), but sex explained
M3 - Article
SN - 0275-5408
VL - 31
SP - 516
EP - 528
JO - Ophthalmic and Physiological Optics
JF - Ophthalmic and Physiological Optics
IS - 5
ER -