Preclinical dosimetry models and the prediction of clinical doses of novel Positron Emission Tomography radiotracers

Adam A. Garrow, Jack Andrews, Zaniah Gonzalez Galofre, Carlos José Alcaide-corral, Christophe Portal, Tim Morgan, Tashfeen Walton, Ian Wilson, David E Newby, Christophe Lucatelli, Adriana A S Tavares

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Dosimetry models using preclinical positron emission tomography (PET) data are commonly employed to predict the clinical radiological safety of novel radiotracers. However, unbiased clinical safety profiling remains difficult during the translational exercise from preclinical research to first-in-human studies for novel PET radiotracers. In this study, we assessed PET dosimetry data of six 18F-labelled radiotracers using preclinical dosimetry models, different reconstruction methods and quantified the biases of these predictions relative to measured clinical doses to ease translation of new PET radiotracers to first-in-human studies. Whole-body PET images were taken from rats over 240 min after intravenous radiotracer bolus injection. Four existing and two novel PET radiotracers were investigated: [18F]FDG, [18F]AlF-NOTA-RGDfK, [18F]AlF-NOTA-octreotide ([18F]AlF-NOTA-OC), [18F]AlF-NOTA-NOC, [18F]ENC2015 and [18F]ENC2018. Filtered-back projection (FBP) and iterative methods were used for reconstruction of PET data. Predicted and true clinical absorbed doses for [18F]FDG and [18F]AlF-NOTA-OC were then used to quantify bias of preclinical model predictions versus clinical measurements. Our results show that most dosimetry models were biased in their predicted clinical dosimetry compared to empirical values. Therefore, normalization of rat:human organ sizes and correction for reconstruction method biases are required to achieve higher precision of dosimetry estimates.
Original languageEnglish
JournalScientific Reports
Early online date29 Sept 2020
Publication statusE-pub ahead of print - 29 Sept 2020


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