Predicting Cardiovascular Stent Complications using self-reporting biosensors for non-invasive detection of disease

Daniel Hoare, Andreas Tsiamis, Jamie Marland, Jakub Czyzewski, Mahmut Talha Kirimi, Michael Holsgrove, Ewan Russell, Steve Neale, Nosrat Mirzai, Srinjoy Mitra, John Mercer

Research output: Contribution to journalArticlepeer-review

Abstract

Self-reporting implantable medical devices are the future of cardiovascular healthcare. Cardiovascular complications such as blocked arteries that lead to the majority of heart attacks and strokes are frequently treated with inert metal stents that reopen affected vessels. Stents frequently re-block after deployment due to a wound response called in-stent restenosis (ISR). Herein, an implantable miniaturized sensor and telemetry system are developed that can detect this process, discern the different cell types associated with ISR, distinguish sub plaque components as demonstrated with ex vivo samples, and differentiate blood from blood clot, all on a silicon substrate making it suitable for integration onto a vascular stent. This work shows that microfabricated sensors can provide clinically relevant information in settings closer to physiological conditions than previous work with cultured cells.

Original languageEnglish
Article number2105285
JournalAdvanced Science
Volume9
Issue number15
Early online date24 Mar 2022
DOIs
Publication statusPublished - 25 May 2022

Keywords

  • blood clot
  • Cardiovascular disease
  • restenosis
  • stent
  • wireless impedance sensor
  • cardiovascular disease
  • Coronary Restenosis/etiology
  • Humans
  • Myocardial Infarction/complications
  • Biosensing Techniques
  • Stents/adverse effects
  • Plaque, Atherosclerotic/complications

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