Predicting genome organisation and function with mechanistic modelling

Michael Chiang, Chris A Brackley, Davide Marenduzzo, Nick Gilbert*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Fitting-free mechanistic models based on polymer simulations predict chromatin folding in 3D by focussing on the underlying biophysical mechanisms. This class of models has been increasingly used in conjunction with experiments to study the spatial organisation of eukaryotic chromosomes. Feedback from experiments to models leads to successive model refinement and has previously led to the discovery of new principles for genome organisation. Here, we review the basis of mechanistic polymer simulations, explain some of the more recent approaches and the contexts in which they have been useful to explain chromosome biology, and speculate on how they might be used in the future.

Original languageEnglish
Pages (from-to)364-378
Number of pages15
JournalTrends in Genetics
Issue number4
Early online date29 Nov 2021
Publication statusPublished - 1 Apr 2022


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