Predicting incident dementia in cerebral small vessel disease: comparison of machine learning and traditional statistical models

Rui Li; Eric l. Harshfield; Steven Bell; Michael Burkhart; Anil m. Tuladhar; Saima Hilal; Daniel j. Tozer; Francesca m. Chappell; Stephen d.j. Makin; Jessica w. Lo; Joanna m. Wardlaw; Frank-Erik De leeuw; Christopher Chen; Zoe Kourtzi; Hugh s. Markus

doi:10.1016/j.cccb.2023.100179

Predicting incident dementia in cerebral small vessel disease: comparison of machine learning and traditional statistical models

Rui Li^*, Eric l. Harshfield, Steven Bell, Michael Burkhart, Anil m. Tuladhar, Saima Hilal, Daniel j. Tozer, Francesca m. Chappell, Stephen d.j. Makin, Jessica w. Lo, Joanna m. Wardlaw, Frank-Erik De leeuw, Christopher Chen, Zoe Kourtzi, Hugh s. Markus

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	100179
Journal	Cerebral Circulation—Cognition and Behavior
Volume	5
DOIs	https://doi.org/10.1016/j.cccb.2023.100179
Publication status	Published - 9 Aug 2023

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10.1016/j.cccb.2023.100179

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https://linkinghub.elsevier.com/retrieve/pii/S2666245023000235

Cite this

Li, R., Harshfield, E. L., Bell, S., Burkhart, M., Tuladhar, A. M., Hilal, S., Tozer, D. J., Chappell, F. M., Makin, S. D. J., Lo, J. W., Wardlaw, J. M., De leeuw, F.-E., Chen, C., Kourtzi, Z., & Markus, H. S. (2023). Predicting incident dementia in cerebral small vessel disease: comparison of machine learning and traditional statistical models. Cerebral Circulation—Cognition and Behavior, 5, 100179. https://doi.org/10.1016/j.cccb.2023.100179

@article{f931e39ef250468eaba3d7adf2763416,

title = "Predicting incident dementia in cerebral small vessel disease: comparison of machine learning and traditional statistical models",

author = "Rui Li and Harshfield, {Eric l.} and Steven Bell and Michael Burkhart and Tuladhar, {Anil m.} and Saima Hilal and Tozer, {Daniel j.} and Chappell, {Francesca m.} and Makin, {Stephen d.j.} and Lo, {Jessica w.} and Wardlaw, {Joanna m.} and {De leeuw}, Frank-Erik and Christopher Chen and Zoe Kourtzi and Markus, {Hugh s.}",

note = "Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was funded by a British Heart Foundation (BHF) programme grant [grant number RG/F/22/110052 ] and infrastructural support was provided by the Cambridge British Heart Foundation Centre of Research Excellence [grant number RE/18/1/34212 ] and the Cambridge University Hospitals NIHR Biomedical Research Centre [grant number BRC-1215–20014 ]. Funding Information: HSM is supported by an NIHR Senior Investigator Award, and a number of peer reviewed funders including Medical Research Council, EU, Alzheimer's Society, Stroke Association, BHF. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. RL is supported by a PhD scholarship awarded by Trinity College, University of Cambridge. ELH is supported by Cambridge BHF Centre of Research Excellence [grant number RE/18/1/34212 ]; Alzheimer's Society [grant number AS-RF-21–017 ]; BHF programme grant [grant number RG/F/22/110052 ]; Cambridge NIHR Biomedical Research Centre [grant number BRC-1215–20014 ]. SB is supported by BHF . AMT is supported by Dutch Heart Foundation [grant number 2016T044 ]. Wellcome Trust [grant number 081589 ] provided initial funding for SCANS study. SDJM is supported by Wellcome Trust [grant number WT088134/Z/09/A ]. JMW is supported by Wellcome Trust , Row Fogo Trust , and Medical Research Council . CC is supported by National Medical Research Council of Singapore. ZK is supported by Wellcome Trust and Alan Turing Institute. Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = aug,

day = "9",

doi = "10.1016/j.cccb.2023.100179",

language = "English",

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Li, R, Harshfield, EL, Bell, S, Burkhart, M, Tuladhar, AM, Hilal, S, Tozer, DJ, Chappell, FM, Makin, SDJ, Lo, JW, Wardlaw, JM, De leeuw, F-E, Chen, C, Kourtzi, Z & Markus, HS 2023, 'Predicting incident dementia in cerebral small vessel disease: comparison of machine learning and traditional statistical models', Cerebral Circulation—Cognition and Behavior, vol. 5, pp. 100179. https://doi.org/10.1016/j.cccb.2023.100179

TY - JOUR

T1 - Predicting incident dementia in cerebral small vessel disease: comparison of machine learning and traditional statistical models

AU - Li, Rui

AU - Harshfield, Eric l.

AU - Bell, Steven

AU - Burkhart, Michael

AU - Tuladhar, Anil m.

AU - Hilal, Saima

AU - Tozer, Daniel j.

AU - Chappell, Francesca m.

AU - Makin, Stephen d.j.

AU - Lo, Jessica w.

AU - Wardlaw, Joanna m.

AU - De leeuw, Frank-Erik

AU - Chen, Christopher

AU - Kourtzi, Zoe

AU - Markus, Hugh s.

N1 - Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was funded by a British Heart Foundation (BHF) programme grant [grant number RG/F/22/110052 ] and infrastructural support was provided by the Cambridge British Heart Foundation Centre of Research Excellence [grant number RE/18/1/34212 ] and the Cambridge University Hospitals NIHR Biomedical Research Centre [grant number BRC-1215–20014 ]. Funding Information: HSM is supported by an NIHR Senior Investigator Award, and a number of peer reviewed funders including Medical Research Council, EU, Alzheimer's Society, Stroke Association, BHF. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. RL is supported by a PhD scholarship awarded by Trinity College, University of Cambridge. ELH is supported by Cambridge BHF Centre of Research Excellence [grant number RE/18/1/34212 ]; Alzheimer's Society [grant number AS-RF-21–017 ]; BHF programme grant [grant number RG/F/22/110052 ]; Cambridge NIHR Biomedical Research Centre [grant number BRC-1215–20014 ]. SB is supported by BHF . AMT is supported by Dutch Heart Foundation [grant number 2016T044 ]. Wellcome Trust [grant number 081589 ] provided initial funding for SCANS study. SDJM is supported by Wellcome Trust [grant number WT088134/Z/09/A ]. JMW is supported by Wellcome Trust , Row Fogo Trust , and Medical Research Council . CC is supported by National Medical Research Council of Singapore. ZK is supported by Wellcome Trust and Alan Turing Institute. Publisher Copyright: © 2023

PY - 2023/8/9

Y1 - 2023/8/9

U2 - 10.1016/j.cccb.2023.100179

DO - 10.1016/j.cccb.2023.100179

M3 - Article

SN - 2666-2450

VL - 5

SP - 100179

JO - Cerebral Circulation—Cognition and Behavior

JF - Cerebral Circulation—Cognition and Behavior

ER -