Prediction of depression symptoms in individual subjects with face and eye movement tracking

Aleks Stolicyn, J. Douglas Steele, Peggy Series

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Depression is a challenge to diagnose reliably and the current gold standard for trials of DSM-5 has been agreement between two or more medical specialists. Research studies aiming to objectively predict depression have typically used brain scanning. Less expensive methods from cognitive neuroscience may allow quicker and more reliable diagnoses, and contribute to reducing the costs of managing the condition. In the current study we aimed to develop a novel inexpensive system for detecting elevated symptoms of depression based on tracking face and eye movements during the performance of cognitive tasks.

Seventy-five participants performed two novel cognitive tasks with verbal affective distraction elements while their face and eye movements were recorded using inexpensive cameras. Data from 48 participants (mean age 25.5 years, standard deviation 6.1 years, 25 with elevated symptoms of depression) passed quality control and were included in a case-control classification analysis with machine learning.

Classification accuracy using cross-validation (within-study replication) reached 79% (sensitivity 76%, specificity 82%), when face and eye movement measures were combined. Symptomatic participants were characterised by less intense mouth and eyelid movements during different stages of the task, and by differences in frequencies and durations of fixations on affectively salient distraction words.

Elevated symptoms of depression can be detected with face and eye movement tracking during cognitive performance, with a close to clinically-relevant accuracy (~ 80%). Future studies should validate these results in larger samples and in clinical populations.
Original languageEnglish
Pages (from-to)1784-1792
Number of pages9
JournalPsychological Medicine
Issue number9
Early online date9 Nov 2020
Publication statusPublished - 1 Jul 2022

Keywords / Materials (for Non-textual outputs)

  • Cognitive tasks
  • depression
  • eye movements
  • eye-tracking
  • face movements
  • machine learning
  • prediction


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