TY - JOUR
T1 - Prediction of development and maintenance of high albuminuria during chronic renin-angiotensin suppression by plasma proteomics
AU - Baldan-Martin, Montserrat
AU - de la Cuesta, Fernando
AU - Alvarez-Llamas, Gloria
AU - Gonzalez-Calero, Laura
AU - Ruiz-Hurtado, Gema
AU - Moreno-Luna, Rafael
AU - Mourino-Alvarez, Laura
AU - Sastre-Oliva, Tamara
AU - Segura, Julian
AU - Padial, Luis R
AU - Vivanco, Fernando
AU - Ruilope, Luis M
AU - Barderas, Maria G
N1 - Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - BACKGROUND: High albuminuria is a strong predictor of development of cardiovascular events in hypertensive patients. The search for predictors identifying patients at risk of developing high albuminuria or presenting a more rapid progression in this parameter may represent an effective strategy for adequate intervention and better outcome.METHODS AND RESULTS: Initially we investigated 24 patients presenting with normoalbuminuria, de novo albuminuria and sustained albuminuria. Plasma proteomics disclosed an upregulation of ceruloplasmin (CP), haptoglobin (HP) and alpha 1-acid glycoprotein (ORM1) that in a second step were selected for validation using turbidimetry assay in a cohort of 105 subjects. The validation showed that HP and ORM1 proteins were increased in patients presenting with very high albuminuria and potential irreversible kidney damage. CP and HP correlated positively with albuminuria values in normoalbuminuric patients. Finally, the levels of ORM1 and CP were increased in patients who progressed in their levels of albuminuria.CONCLUSIONS: Our findings show that these proteins may potentially be useful for predicting the development of high albuminuria and to monitor renal damage.
AB - BACKGROUND: High albuminuria is a strong predictor of development of cardiovascular events in hypertensive patients. The search for predictors identifying patients at risk of developing high albuminuria or presenting a more rapid progression in this parameter may represent an effective strategy for adequate intervention and better outcome.METHODS AND RESULTS: Initially we investigated 24 patients presenting with normoalbuminuria, de novo albuminuria and sustained albuminuria. Plasma proteomics disclosed an upregulation of ceruloplasmin (CP), haptoglobin (HP) and alpha 1-acid glycoprotein (ORM1) that in a second step were selected for validation using turbidimetry assay in a cohort of 105 subjects. The validation showed that HP and ORM1 proteins were increased in patients presenting with very high albuminuria and potential irreversible kidney damage. CP and HP correlated positively with albuminuria values in normoalbuminuric patients. Finally, the levels of ORM1 and CP were increased in patients who progressed in their levels of albuminuria.CONCLUSIONS: Our findings show that these proteins may potentially be useful for predicting the development of high albuminuria and to monitor renal damage.
U2 - 10.1016/j.ijcard.2015.05.148
DO - 10.1016/j.ijcard.2015.05.148
M3 - Article
C2 - 26119064
VL - 196
SP - 170
EP - 177
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -