Prediction of partition coefficients by multiscale hybrid atomic-level/coarse-grain simulations

Julien Michel, Mario Orsi, Jonathan W. Essex

Research output: Contribution to journalArticlepeer-review

Abstract

Coarse-grain models are becoming an increasingly important tool in computer simulations. of a wide variety of molecular processes. In many instances it is, however, desirable to describe key portions of a molecular system at the atomic level. There is therefore a strong interest in the development of simulation methodologies that allow representations of matter with mixed granularities in a multiscale fashion. We report here a strategy to conduct mixed atomic-level and coarse-grain simulations of molecular systems with a recently developed coarse-grain model. The methodology is validated by computing partition coefficients of small molecules described in atomic detail and solvated by water or octane, both of which are represented by coarse-grain models. Because the present coarse-grain force field retains electrostatic interactions, the simplified solvent particles can interact realistically with the all-atom solutes. The partition coefficients computed by this approach rival the accuracy of fully atomistic simulations and are obtained at a fraction of their computational cost. The present methodology is simple, robust and applicable to a wide variety of molecular systems.

Original languageEnglish
Pages (from-to)657-660
Number of pages4
JournalJournal of Physical Chemistry B (Soft Condensed Matter and Biophysical Chemistry)
Volume112
Issue number3
DOIs
Publication statusPublished - 24 Jan 2008

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