Predictors of longitudinal cognitive ageing from age 70 to 82 including APOE e4 status, early-life and lifestyle factors: The Lothian Birth Cohort 1936

Janie Corley; Federica Conte; Sarah E. Harris; Adele M. Taylor; Paul Redmond; Tom C. Russ; Ian J. Deary; Simon R. Cox

doi:10.1038/s41380-022-01900-4

Predictors of longitudinal cognitive ageing from age 70 to 82 including APOE e4 status, early-life and lifestyle factors: The Lothian Birth Cohort 1936

Janie Corley, Federica Conte, Sarah E. Harris, Adele M. Taylor, Paul Redmond, Tom C. Russ, Ian J. Deary, Simon R. Cox

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Discovering why some people’s cognitive abilities decline more than others is a key challenge for cognitive ageing research. The most effective strategy may be to address multiple risk factors from across the life-course simultaneously in relation to robust longitudinal cognitive data. We conducted a 12-year follow-up of 1091 (at age 70) men and women from the longitudinal Lothian Birth Cohort 1936 study. Comprehensive repeated cognitive measures of visuospatial ability, processing speed, memory, verbal ability, and a general cognitive factor, were collected over five assessments (age 70, 73, 76, 79, and 82 years) and analysed using multivariate latent growth curve modelling. Fifteen life-course variables were used to predict variation in cognitive ability levels at age 70 and cognitive slopes from age 70 to 82. Only APOE e4 carrier status was found to be reliably informative of general- and domain-specific cognitive decline, despite there being many life-course correlates of cognitive level at age 70. APOE e4 carriers had significantly steeper slopes across all three fluid cognitive domains compared with non-carriers, especially for memory (β = −0.234, P< 0.001) and general cognitive function (β = −0.246, P

Original language	English
Journal	Molecular Psychiatry
Early online date	8 Dec 2022
DOIs	https://doi.org/10.1038/s41380-022-01900-4
Publication status	E-pub ahead of print - 8 Dec 2022

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CorleyEtalMP2022PredictorsOfLongitudinalFinal published version, 1.07 MBLicence: Creative Commons: Attribution (CC-BY)

https://doi.org/10.1038/s41380-022-01900-4Licence: Creative Commons: Attribution (CC-BY)

1 Active
3 Finished

Factors of biological ageing: does it all go together when it goes?
Cox, S.
UK-based charities
1/05/21 → 30/04/26
Project: Research
Brain imaging and cognitive ageing in the Lothian Birth Cohort 1936: III
Wardlaw, J., Bastin, M. & Deary, I.
MRC
1/05/15 → 30/04/19
Project: Research
MRC Dementias Platform
Deary, I.
Other
1/04/14 → 31/03/20
Project: Research

Cite this

@article{421124b011bb4e889105aefbd5c23dd6,

title = "Predictors of longitudinal cognitive ageing from age 70 to 82 including APOE e4 status, early-life and lifestyle factors: The Lothian Birth Cohort 1936",

abstract = "Discovering why some people{\textquoteright}s cognitive abilities decline more than others is a key challenge for cognitive ageing research. The most effective strategy may be to address multiple risk factors from across the life-course simultaneously in relation to robust longitudinal cognitive data. We conducted a 12-year follow-up of 1091 (at age 70) men and women from the longitudinal Lothian Birth Cohort 1936 study. Comprehensive repeated cognitive measures of visuospatial ability, processing speed, memory, verbal ability, and a general cognitive factor, were collected over five assessments (age 70, 73, 76, 79, and 82 years) and analysed using multivariate latent growth curve modelling. Fifteen life-course variables were used to predict variation in cognitive ability levels at age 70 and cognitive slopes from age 70 to 82. Only APOE e4 carrier status was found to be reliably informative of general- and domain-specific cognitive decline, despite there being many life-course correlates of cognitive level at age 70. APOE e4 carriers had significantly steeper slopes across all three fluid cognitive domains compared with non-carriers, especially for memory (β = −0.234, P< 0.001) and general cognitive function (β = −0.246, P",

author = "Janie Corley and Federica Conte and Harris, {Sarah E.} and Taylor, {Adele M.} and Paul Redmond and Russ, {Tom C.} and Deary, {Ian J.} and Cox, {Simon R.}",

note = "This research was funded in whole, or in part, by the Wellcome Trust [221890/Z/20/Z]. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. We gratefully acknowledge the contributions of the LBC1936 participants and members of the LBC1936 research team who collect and manage the LBC data. We also thank the Genetics Core staff at the Edinburgh Clinical Research Facility. The LBC1936 is supported by Age UK [The Disconnected Mind], the Medical Research Council [G0701120, G1001245, MR/M01311/1, MR/R024065/1] and the University of Edinburgh. SRC and IJD were additionally supported by a National Institutes of Health (NIH) research grant R01AG054628, and IJD was also supported by the Dementias Platform UK [MR/L015382/1]. SRC is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 221890/Z/20/Z). ).",

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AU - Corley, Janie

AU - Conte, Federica

AU - Harris, Sarah E.

AU - Taylor, Adele M.

AU - Redmond, Paul

AU - Russ, Tom C.

AU - Deary, Ian J.

AU - Cox, Simon R.

N1 - This research was funded in whole, or in part, by the Wellcome Trust [221890/Z/20/Z]. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. We gratefully acknowledge the contributions of the LBC1936 participants and members of the LBC1936 research team who collect and manage the LBC data. We also thank the Genetics Core staff at the Edinburgh Clinical Research Facility. The LBC1936 is supported by Age UK [The Disconnected Mind], the Medical Research Council [G0701120, G1001245, MR/M01311/1, MR/R024065/1] and the University of Edinburgh. SRC and IJD were additionally supported by a National Institutes of Health (NIH) research grant R01AG054628, and IJD was also supported by the Dementias Platform UK [MR/L015382/1]. SRC is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 221890/Z/20/Z). ).

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N2 - Discovering why some people’s cognitive abilities decline more than others is a key challenge for cognitive ageing research. The most effective strategy may be to address multiple risk factors from across the life-course simultaneously in relation to robust longitudinal cognitive data. We conducted a 12-year follow-up of 1091 (at age 70) men and women from the longitudinal Lothian Birth Cohort 1936 study. Comprehensive repeated cognitive measures of visuospatial ability, processing speed, memory, verbal ability, and a general cognitive factor, were collected over five assessments (age 70, 73, 76, 79, and 82 years) and analysed using multivariate latent growth curve modelling. Fifteen life-course variables were used to predict variation in cognitive ability levels at age 70 and cognitive slopes from age 70 to 82. Only APOE e4 carrier status was found to be reliably informative of general- and domain-specific cognitive decline, despite there being many life-course correlates of cognitive level at age 70. APOE e4 carriers had significantly steeper slopes across all three fluid cognitive domains compared with non-carriers, especially for memory (β = −0.234, P< 0.001) and general cognitive function (β = −0.246, P

AB - Discovering why some people’s cognitive abilities decline more than others is a key challenge for cognitive ageing research. The most effective strategy may be to address multiple risk factors from across the life-course simultaneously in relation to robust longitudinal cognitive data. We conducted a 12-year follow-up of 1091 (at age 70) men and women from the longitudinal Lothian Birth Cohort 1936 study. Comprehensive repeated cognitive measures of visuospatial ability, processing speed, memory, verbal ability, and a general cognitive factor, were collected over five assessments (age 70, 73, 76, 79, and 82 years) and analysed using multivariate latent growth curve modelling. Fifteen life-course variables were used to predict variation in cognitive ability levels at age 70 and cognitive slopes from age 70 to 82. Only APOE e4 carrier status was found to be reliably informative of general- and domain-specific cognitive decline, despite there being many life-course correlates of cognitive level at age 70. APOE e4 carriers had significantly steeper slopes across all three fluid cognitive domains compared with non-carriers, especially for memory (β = −0.234, P< 0.001) and general cognitive function (β = −0.246, P

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DO - 10.1038/s41380-022-01900-4

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SN - 1359-4184

JO - Molecular Psychiatry

JF - Molecular Psychiatry

ER -

Predictors of longitudinal cognitive ageing from age 70 to 82 including APOE e4 status, early-life and lifestyle factors: The Lothian Birth Cohort 1936

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Projects

Factors of biological ageing: does it all go together when it goes?

Brain imaging and cognitive ageing in the Lothian Birth Cohort 1936: III

MRC Dementias Platform

Cite this