Premature senescence in cells from patients with autosomal recessive hypercholesterolemia (ARH): evidence for a role for ARH in mitosis

Xi-Ming Sun; Dilip D Patel; Juan Acosta; Jesùs Gil; Anne K Soutar

doi:10.1161/ATVBAHA.111.232223

Premature senescence in cells from patients with autosomal recessive hypercholesterolemia (ARH): evidence for a role for ARH in mitosis

Xi-Ming Sun, Dilip D Patel, Juan Acosta, Jesùs Gil, Anne K Soutar

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The defective gene causing autosomal recessive hypercholesterolemia (ARH) encodes ARH, a clathrin-associated adaptor protein required for low-density-lipoprotein receptor endocytosis in most cells but not in skin fibroblasts. The aim here was to elucidate why ARH fibroblasts grow slowly and undergo premature senescence.

Original language	English
Pages (from-to)	2270-7
Number of pages	8
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	31
Issue number	10
DOIs	https://doi.org/10.1161/ATVBAHA.111.232223
Publication status	Published - Oct 2011

Keywords / Materials (for Non-textual outputs)

Atherosclerosis
Cell Nucleus Shape
Mass Spectrometry
Mitotic Spindle Apparatus
Histones
Humans
Nuclear Envelope
Cell Shape
Cell Proliferation
Fibroblasts
Cyclin-Dependent Kinase Inhibitor p16
Mutagenesis, Site-Directed
Phenotype
Phosphorylation
Adaptor Proteins, Signal Transducing
Mitosis
RNA Interference
Time Factors
Hypercholesterolemia
Microtubules
Skin
HeLa Cells
Genotype
Cyclin B
Lamin Type B
Transfection
Cell Aging
Case-Control Studies
Mutation

Access to Document

10.1161/ATVBAHA.111.232223

Cite this

@article{769ca41fa34e4a20870f63b78804de8f,

title = "Premature senescence in cells from patients with autosomal recessive hypercholesterolemia (ARH): evidence for a role for ARH in mitosis",

abstract = "The defective gene causing autosomal recessive hypercholesterolemia (ARH) encodes ARH, a clathrin-associated adaptor protein required for low-density-lipoprotein receptor endocytosis in most cells but not in skin fibroblasts. The aim here was to elucidate why ARH fibroblasts grow slowly and undergo premature senescence.",

keywords = "Atherosclerosis, Cell Nucleus Shape, Mass Spectrometry, Mitotic Spindle Apparatus, Histones, Humans, Nuclear Envelope, Cell Shape, Cell Proliferation, Fibroblasts, Cyclin-Dependent Kinase Inhibitor p16, Mutagenesis, Site-Directed, Phenotype, Phosphorylation, Adaptor Proteins, Signal Transducing, Mitosis, RNA Interference, Time Factors, Hypercholesterolemia, Microtubules, Skin, HeLa Cells, Genotype, Cyclin B, Lamin Type B, Transfection, Cell Aging, Case-Control Studies, Mutation",

author = "Xi-Ming Sun and Patel, {Dilip D} and Juan Acosta and Jes{\`u}s Gil and Soutar, {Anne K}",

year = "2011",

month = oct,

doi = "10.1161/ATVBAHA.111.232223",

language = "English",

volume = "31",

pages = "2270--7",

journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",

issn = "1524-4636",

publisher = "Lippincott Williams & Wilkins",

number = "10",

}

TY - JOUR

T1 - Premature senescence in cells from patients with autosomal recessive hypercholesterolemia (ARH)

T2 - evidence for a role for ARH in mitosis

AU - Sun, Xi-Ming

AU - Patel, Dilip D

AU - Acosta, Juan

AU - Gil, Jesùs

AU - Soutar, Anne K

PY - 2011/10

Y1 - 2011/10

N2 - The defective gene causing autosomal recessive hypercholesterolemia (ARH) encodes ARH, a clathrin-associated adaptor protein required for low-density-lipoprotein receptor endocytosis in most cells but not in skin fibroblasts. The aim here was to elucidate why ARH fibroblasts grow slowly and undergo premature senescence.

AB - The defective gene causing autosomal recessive hypercholesterolemia (ARH) encodes ARH, a clathrin-associated adaptor protein required for low-density-lipoprotein receptor endocytosis in most cells but not in skin fibroblasts. The aim here was to elucidate why ARH fibroblasts grow slowly and undergo premature senescence.

KW - Atherosclerosis

KW - Cell Nucleus Shape

KW - Mass Spectrometry

KW - Mitotic Spindle Apparatus

KW - Histones

KW - Humans

KW - Nuclear Envelope

KW - Cell Shape

KW - Cell Proliferation

KW - Fibroblasts

KW - Cyclin-Dependent Kinase Inhibitor p16

KW - Mutagenesis, Site-Directed

KW - Phenotype

KW - Phosphorylation

KW - Adaptor Proteins, Signal Transducing

KW - Mitosis

KW - RNA Interference

KW - Time Factors

KW - Hypercholesterolemia

KW - Microtubules

KW - Skin

KW - HeLa Cells

KW - Genotype

KW - Cyclin B

KW - Lamin Type B

KW - Transfection

KW - Cell Aging

KW - Case-Control Studies

KW - Mutation

U2 - 10.1161/ATVBAHA.111.232223

DO - 10.1161/ATVBAHA.111.232223

M3 - Article

C2 - 21778424

SN - 1524-4636

VL - 31

SP - 2270

EP - 2277

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

IS - 10

ER -

Premature senescence in cells from patients with autosomal recessive hypercholesterolemia (ARH): evidence for a role for ARH in mitosis

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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