Premature senescence in cells from patients with autosomal recessive hypercholesterolemia (ARH): evidence for a role for ARH in mitosis

Xi-Ming Sun, Dilip D Patel, Juan Acosta, Jesùs Gil, Anne K Soutar

Research output: Contribution to journalArticlepeer-review

Abstract

The defective gene causing autosomal recessive hypercholesterolemia (ARH) encodes ARH, a clathrin-associated adaptor protein required for low-density-lipoprotein receptor endocytosis in most cells but not in skin fibroblasts. The aim here was to elucidate why ARH fibroblasts grow slowly and undergo premature senescence.
Original languageEnglish
Pages (from-to)2270-7
Number of pages8
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume31
Issue number10
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Atherosclerosis
  • Cell Nucleus Shape
  • Mass Spectrometry
  • Mitotic Spindle Apparatus
  • Histones
  • Humans
  • Nuclear Envelope
  • Cell Shape
  • Cell Proliferation
  • Fibroblasts
  • Cyclin-Dependent Kinase Inhibitor p16
  • Mutagenesis, Site-Directed
  • Phenotype
  • Phosphorylation
  • Adaptor Proteins, Signal Transducing
  • Mitosis
  • RNA Interference
  • Time Factors
  • Hypercholesterolemia
  • Microtubules
  • Skin
  • HeLa Cells
  • Genotype
  • Cyclin B
  • Lamin Type B
  • Transfection
  • Cell Aging
  • Case-Control Studies
  • Mutation

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