Projects per year
Abstract
ACTH and corticosterone responses to an acute stressor were markedly enhanced in F2 PNS females compared with controls. This was associated with greater corticotropin releasing hormone (Crh) mRNA expression in the paraventricular nucleus and reduced hippocampal glucocorticoid (Gr) and mineralocorticoid receptor (Mr) mRNA expression. Conversely, in the F2 PNS males, HPA axis responses to acute stress were attenuated and hippocampal Gr mRNA expression was greater compared with controls.
F2 PNS males exhibited heightened anxiety-like behavior (light-dark box and elevated plus maze) compared with F2 control males. Anxiety-like behavior did not differ between F2 control and PNS females during metestrus/diestrus, however at proestrus/estrus, F2 control females displayed a reduction in anxiety-like behavior, but this effect was not observed in the F2 PNS females. Heightened anxiety in the F2 PNS males was associated with greater Crh mRNA expression in the central nucleus of the amygdala compared with controls. Moreover, Crh receptor-1 (Crhr1) mRNA expression was significantly increased, whereas Crhr2 mRNA was significantly decreased in discrete regions of the amygdala in F2 PNS males compared with controls, with no differences in the F2 females. No differences in depressive-like behavior (sucrose preference or forced swim test) were observed in either sex. In conclusion, the effects of maternal stress during pregnancy on HPA axis regulation and anxiety-like behavior can be transmitted to future generations in a sex-dependent manner. These data have implications for human neuropsychiatric disorders with developmental origins.
Original language | English |
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Pages (from-to) | 204-216 |
Journal | Psychoneuroendocrinology |
Volume | 62 |
Early online date | 18 Aug 2015 |
DOIs | |
Publication status | Published - 2015 |
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Dive into the research topics of 'Prenatal stress programs neuroendocrine stress responses and affective behaviors in second generation rats in a sex-dependent manner'. Together they form a unique fingerprint.Projects
- 2 Finished
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Livestock neurobiology
Gill, A. (Principal Investigator), Barron, R. (Co-investigator), Beard, P. (Co-investigator), Brunton, P. (Co-investigator), Goldmann, W. (Co-investigator), Hume, D. (Co-investigator), Hunter, N. (Co-investigator), Lawrence, A. (Co-investigator), Mabbott, N. (Co-investigator), Manson, J. (Co-investigator), McColl, B. (Co-investigator), Meddle, S. (Co-investigator) & Wishart, T. (Co-investigator)
1/04/12 → 31/03/17
Project: Research
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Doctoral training grant for 16 students
Hume, D. (Principal Investigator), Goldmann, W. (Co-investigator) & MacRae, V. (Co-investigator)
1/10/09 → 30/09/15
Project: Research
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Trans-generational effects of maternal exposure to social stress on anxiety-like behaviour in rats
Grundwald, N. & Brunton, P., 1 Nov 2015, In: Psychoneuroendocrinology. 61, p. 22Research output: Contribution to journal › Meeting abstract › peer-review
Open AccessFile -
Trans-generational effects of prenatal stress on the neuroendocrine stress axis in rats
Grundwald, N. J. & Brunton, P. J., 1 Nov 2015, In: Psychoneuroendocrinology. 61, p. 30Research output: Contribution to journal › Meeting abstract › peer-review
Open AccessFile -
Trans-generational effects of maternal exposure to social stress on anxiety-like behaviour in rats
Grundwald, N. J. & Brunton, P., 2015, (Unpublished).Research output: Contribution to conference › Poster
Profiles
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Paula Brunton
- Centre for Discovery Brain Sciences
- Deanery of Biomedical Sciences - Senior Lecturer (Zhejiang)
- Edinburgh Neuroscience
Person: Academic: Research Active