Preparation and crystal structure of a trihydrate of paracetamol

P A McGregor, D R Allan, S Parsons, C R Pulham

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

This work reports the preparation and crystal structure of a trihydrate of paracetamol. Crystals were grown by slow cooling of an aqueous solution of paracetamol to 0degreesC. Single-crystal X-ray diffraction shows that the trihydrate crystallizes in the orthorhombic crystal system, space group Pbca, Z = 8, a = 7.3324(16), b = 12.590(3), c = 22.636(6) Angstrom, V = 2089.7(9) Angstrom(3). The crystals of the trihydrate dehydrate rapidly at 20degreesC to give anhydrous paracetamol as its monoclinic form. (C) 2002 Wiley-Liss, Inc. and the American Pharmaceutical Association.

Original languageEnglish
Pages (from-to)1308-1311
Number of pages4
JournalJournal of Pharmaceutical Sciences
Issue number5
Publication statusPublished - May 2002


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