Presentation, diagnostic assessment and surgical outcomes in primary hyperparathyroidism: a single centre's experience

Laura Reid, Bala Muthukrishnan, Dilip Patel, Mike Crane, Murat Akyol, Andrew Thomson, Jonathan R Seckl, Fraser Wilson Gibb

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

OBJECTIVE: Primary hyperparathyroidism (PHPT) is a common reason for referral to endocrinology but the evidence base guiding assessment is limited. We evaluated the clinical presentation, assessment and subsequent management in PHPT.

DESIGN: Retrospective cohort study.

PATIENTS: PHPT assessed between 2006 - 2014 (n = 611) in a university hospital.

MEASUREMENTS: Symptoms, clinical features, biochemistry, neck radiology and surgical outcomes.

RESULTS: Fatigue (23.8%), polyuria (15.6%) and polydipsia (14.9%) were associated with PHPT biochemistry. Bone fracture was present in 16.4% but was not associated with biochemistry. A history of nephrolithiasis (10.0%) was associated only with younger age (P = 0.006) and male gender (P = 0.037). Thiazide diuretic discontinuation was not associated with any subsequent change in calcium (P = 0.514). Urine calcium creatinine clearance ratio (CCCR) was <0.01 in 18.2% of patients with confirmed PHPT. Older age (P < 0.001) and lower PTH (P = 0.043) were associated with failure to locate an adenoma on ultrasound (44.0% of scans). When an adenoma was identified on ultrasound the lateralization was correct in 94.5%. Non-curative surgery occurred in 8.2% and was greater in those requiring more than one neck imaging modality (OR 2.42, P = 0.035).

CONCLUSIONS: Clinical features associated with PHPT are not strongly related to biochemistry. Thiazide cessation does not appear to attenuate hypercalcaemia. PHPT remains the likeliest diagnosis in the presence of low CCCR. Ultrasound is highly discriminant when an adenoma is identified but surgical failure is more likely when more than one imaging modality is required.

Original languageEnglish
JournalEndocrine connections
Early online date23 Aug 2018
Publication statusE-pub ahead of print - 23 Aug 2018


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